Regulation of signaling pathways in hair follicle stem cells

Xiaoxiang Wang; Yinghui Liu; Jia He; Jingru Wang; Xiaodong Chen; Ronghua Yang

doi:10.1093/burnst/tkac022

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Regulation of signaling pathways in hair follicle stem cells

更新时间：2023-09-05

- Regulation of signaling pathways in hair follicle stem cells
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
  
  1. Department of Burn Surgery
  2. Guangdong Medical University
  3. Department of Dermatology
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac022
  CLC：
- Published：2022，
  
  Published Online：4 July 2022，
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Xiaoxiang Wang, Yinghui Liu, Jia He, Jingru Wang, Xiaodong Chen, Ronghua Yang, Regulation of signaling pathways in hair follicle stem cells, Burns & Trauma, Volume 10, 2022, tkac022, https://doi.org/10.1093/burnst/tkac022
DOI：

Xiaoxiang Wang, Yinghui Liu, Jia He, Jingru Wang, Xiaodong Chen, Ronghua Yang, Regulation of signaling pathways in hair follicle stem cells, Burns & Trauma, Volume 10, 2022, tkac022, https://doi.org/10.1093/burnst/tkac022 DOI：

摘要

Abstract

Hair follicle stem cells (HFSCs) reside in the bulge region of the outer root sheath of the hair follicle. They are considered slow-cycling cells that are endowed with multilineage differentiation potential and superior proliferative capacity. The normal morphology and periodic growth of HFSCs play a significant role in normal skin functions

wound repair and skin regeneration. The HFSCs involved in these pathophysiological processes are regulated by a series of cell signal transduction pathways

such as lymphoid enhancer factor/T-cell factor

Wnt/β-catenin

transforming growth factor-β/bone morphogenetic protein

Notch and Hedgehog. The mechanisms of the interactions among these signaling pathways and their regulatory effects on HFSCs have been previously studied

but many mechanisms are still unclear. This article reviews the regulation of hair follicles

HFSCs and related signaling pathways

with the aims of summarizing previous research results

revealing the regulatory mechanisms of HFSC proliferation and differentiation and providing important references and new ideas for treating clinical diseases.

关键词

Keywords

Hair follicle stem cellsSignaling pathwaysProliferationDifferentiationRegenerativeRepair

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