Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells

Lucy W Barrett; Vanessa S Fear; Bree Foley; Katherine Audsley; Samantha Barnes; Hannah Newnes; Alison McDonnell; Fiona M Wood; Mark W Fear; Jason Waithman

doi:10.1093/burnst/tkac016

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Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells

更新时间：2022-06-09

- Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
  
  1. Burn Injury Research Unit
  2. Telethon Kids Institute
  3. Fiona Wood Foundation
  4. Burns Service of Western Australia
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac016
  CLC：
- Published：2022，
  
  Published Online：29 April 2022，
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Lucy W Barrett, Vanessa S Fear, Bree Foley, Katherine Audsley, Samantha Barnes, Hannah Newnes, Alison McDonnell, Fiona M Wood, Mark W Fear, Jason Waithman, Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells, Burns & Trauma, Volume 10, 2022, tkac016, https://doi.org/10.1093/burnst/tkac016
DOI：

Lucy W Barrett, Vanessa S Fear, Bree Foley, Katherine Audsley, Samantha Barnes, Hannah Newnes, Alison McDonnell, Fiona M Wood, Mark W Fear, Jason Waithman, Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells, Burns & Trauma, Volume 10, 2022, tkac016, https://doi.org/10.1093/burnst/tkac016 DOI：

摘要

Abstract

BackgroundRecent evidence suggests that burn patients are at increased risk of hospital admission for infection

mental health conditions

cardiovascular disease and cancer for many years after discharge for the burn injury itself. Burn injury has also been shown to induce sustained immune system dysfunction. This change to immune function may contribute to the increased risk of chronic disease observed. However

the mechanisms that disrupt long-term immune function in response to burn trauma

and their link to long-term morbidity

remain unknown. In this study we investigated changes to immune function after burn injury using a murine model of non-severe injury.MethodsAn established mouse model of non-severe burn injury (full thickness burn equivalent to 8% total body surface area) was used in combination with an orthotopic model of B16 melanoma to investigate the link between burns and cancer. Considering that CD8+ T cells are important drivers of effective tumour suppression in this model

we also investigated potential dysregulation of this immune population using mouse models of burn injury in combination with herpes simplex virus infection. Flow cytometry was used to detect and quantify cell populations of interest and changes in immune function.ResultsWe demonstrate that 4 weeks after a non-severe burn injury

mice were significantly more susceptible to tumour development than controls using an orthotopic model of B16 melanoma. In addition

our results reveal that CD8+ T cell expansion

differentiation and memory potential is significantly impaired at 1 month post-burn.ConclusionsOur data suggests that CD8+ T cell-mediated immunity may be dysfunctional for a sustained period after even non-severe burn injury. Further studies in patients to validate these findings may support clinical intervention to restore or protect immunity in patients after burn injury and reduce the increased risk of secondary morbidities observed.

关键词

Keywords

ImmunologySurgeryBurn injuryT cellsImmune dysfunctionCancer

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