Control of fibrosis and hypertrophic scar formation via glycolysis regulation with IR780

Xinxian Meng; Zhixi Yu; Wanyu Xu; Jun Chai; Shuo Fang; Peiru Min; Yunsheng Chen; Yixin Zhang; Zheng Zhang

doi:10.1093/burnst/tkac015

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Control of fibrosis and hypertrophic scar formation via glycolysis regulation with IR780

更新时间：2023-09-05

- Control of fibrosis and hypertrophic scar formation via glycolysis regulation with IR780
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
  
  1. Department of Plastic and Reconstructive Surgery
  2. School of Medicine
  3. Department of Plastic and Reconstructive Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal hospital, Gusu school, Nanjing Medical University
  4. Department of Plastic and Reconstruction, First Affiliated Hospital of Naval Medical University
  5. Department of Burns and Plastic Surgery
  6. Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac015
  CLC：
- Published：2022，
  
  Published Online：24 June 2022，
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Xinxian Meng, Zhixi Yu, Wanyu Xu, Jun Chai, Shuo Fang, Peiru Min, Yunsheng Chen, Yixin Zhang, Zheng Zhang, Control of fibrosis and hypertrophic scar formation via glycolysis regulation with IR780, Burns & Trauma, Volume 10, 2022, tkac015, https://doi.org/10.1093/burnst/tkac015
DOI：

Xinxian Meng, Zhixi Yu, Wanyu Xu, Jun Chai, Shuo Fang, Peiru Min, Yunsheng Chen, Yixin Zhang, Zheng Zhang, Control of fibrosis and hypertrophic scar formation via glycolysis regulation with IR780, Burns & Trauma, Volume 10, 2022, tkac015, https://doi.org/10.1093/burnst/tkac015 DOI：

摘要

Abstract

BackgroundHypertrophic scars (HS) represent one of the most common clinical challenges due to unsatisfactory therapeutic results. HS formation is associated with the abnormal activation of fibroblasts and their excessive fibrotic behavior. Glycolysis dysregulation has been shown to participate in the incidence and progression of various fibrotic diseases and shows potential as a means of controlling HS formation. This work aimed to discuss the impact of augmented glycolysis on HS and to propose a method for controlling HS formation through glycolysis regulation.MethodsHere

augmented glycolysis was confirmed together with enhanced fibrotic activity in both HS fibroblasts (HFs) and HS tissues

and the suppression of glycolysis also attenuated fibroblast activation. We also introduced IR780

a heptamethine cyanine dye

to regulate glycolysis for the control of HS formation.ResultsIn vitro

cell studies indicated that IR780 significantly down-regulated glycolysis and suppressed the fibrotic activity of HFs. In vivo

the intralesional injection of IR780 into rabbit HS models led to the downregulation of glycolysis and the control of HS formation. Furthermore

IR780 accumulated preferentially in activated fibroblasts in both in vitro and in vivo studies

and thus specifically downregulated glycolysis and efficiently controlled fibrosis by targeting activated fibroblasts.ConclusionsThis work identified a strategy for controlling fibrosis and HS formation from the perspective of glycolysis regulation with IR780 targeting of activated fibroblasts.

关键词

Keywords

Hypertrophic scarGlycolysisFibrosisIR780Activated fibroblast

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