Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
1. School of Pharmacy
2. Nanjing University of Chinese Medicine
3. Department of Burns and Plastic Surgery, The affiliated Drum Tow Hospital of Nanjing University of Chinese Medicine
4. Burns Injury and Reconstructive Surgery Research
5. University of Sydney
6. Burns Unit, Concord Repatriation General Hospital
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac014
CLC：Published：2022，
Published Online：21 May 2022，
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Xiaotong Ding, Qinghan Tang, Zeyu Xu, Ye Xu, Hao Zhang, Dongfeng Zheng, Shuqin Wang, Qian Tan, Joanneke Maitz, Peter K Maitz, Shaoping Yin, Yiwei Wang, Jun Chen, Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice, Burns & Trauma, Volume 10, 2022, tkac014, https://doi.org/10.1093/burnst/tkac014
Xiaotong Ding, Qinghan Tang, Zeyu Xu, Ye Xu, Hao Zhang, Dongfeng Zheng, Shuqin Wang, Qian Tan, Joanneke Maitz, Peter K Maitz, Shaoping Yin, Yiwei Wang, Jun Chen, Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice, Burns & Trauma, Volume 10, 2022, tkac014, https://doi.org/10.1093/burnst/tkac014 DOI：
摘要
Abstract
Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and mortality. The underlying mechanism of infections has been widely investigated by scientist
while standard wound management is routinely been used in general practice. However
strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization
delayed healing and drug resistance. In the present review
we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis
non-surgical methods and surgical methods. Moreover
we highlight emerging innovations in the development of antimicrobial peptides
phages
controlled drug delivery
wound dressing materials and herbal medicine
and find that sensitive diagnostics
combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection.
关键词
Keywords
Wound infectionsSkin microbiomeDiagnosisAntimicrobial wound dressingsHerbal medicineHydrogelsAntimicrobial peptidesPhagesDrug delivery
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