Epithelial–mesenchymal transition in organ fibrosis development: current understanding and treatment strategies

Lexin Liu; Qizhe Sun; Frank Davis; Jianhua Mao; Hailin Zhao; Daqing Ma

doi:10.1093/burnst/tkac011

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Epithelial–mesenchymal transition in organ fibrosis development: current understanding and treatment strategies

更新时间：2022-06-09

- Epithelial–mesenchymal transition in organ fibrosis development: current understanding and treatment strategies
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
  
  1. Division of Anaesthetics
  2. Imperial College London, Chelsea and Westminster Hospital
  3. Department of Nephrology and Urology
  4. The Children’s Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health
  5. Department of Nephrology
  6. The Children Hospital of Zhejiang University, School of Medicine
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac011
  CLC：
- Published：2022，
  
  Published Online：8 April 2022，
扫描看全文
Lexin Liu, Qizhe Sun, Frank Davis, Jianhua Mao, Hailin Zhao, Daqing Ma, Epithelial–mesenchymal transition in organ fibrosis development: current understanding and treatment strategies, Burns & Trauma, Volume 10, 2022, tkac011, https://doi.org/10.1093/burnst/tkac011
DOI：

Lexin Liu, Qizhe Sun, Frank Davis, Jianhua Mao, Hailin Zhao, Daqing Ma, Epithelial–mesenchymal transition in organ fibrosis development: current understanding and treatment strategies, Burns & Trauma, Volume 10, 2022, tkac011, https://doi.org/10.1093/burnst/tkac011 DOI：

摘要

Abstract

Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular matrix is excessively deposited. Fibrosis can lead to vital organ failure and there are no effective treatments yet. Although epithelial–mesenchymal transition (EMT) may be one of the key cellular mechanisms

the underlying mechanisms of fibrosis remain largely unknown. EMT is a cell phenotypic process in which epithelial cells lose their cell-to-cell adhesion and polarization

after which they acquire mesenchymal features such as infiltration and migration ability. Upon injurious stimulation in different organs

EMT can be triggered by multiple signaling pathways and is also regulated by epigenetic mechanisms. This narrative review summarizes the current understanding of the underlying mechanisms of EMT in fibrogenesis and discusses potential strategies for attenuating EMT to prevent and/or inhibit fibrosis. Despite better understanding the role of EMT in fibrosis development

targeting EMT and beyond in developing therapeutics to tackle fibrosis is challenging but likely feasible.

关键词

Keywords

EMTFibrosisTGF-βSmadHDAC inhibitorsTGF-β antibodyOrgan fibrosisSenescenceExtracellular matrix

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