Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
1. Psychiatric Laboratory and Mental Health Center
2. West China Hospital of Sichuan University
3. State Key Laboratory of Oral Diseases
4. Sichuan University
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac006
CLC：Published：2022，
Published Online：10 March 2022，
扫 描 看 全 文
Yikai Dou, Weitong Cui, Xiao Yang, Yunfeng Lin, Xiaohong Ma, Xiaoxiao Cai, Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration, Burns & Trauma, Volume 10, 2022, tkac006, https://doi.org/10.1093/burnst/tkac006
摘要
Abstract
Tetrahedral DNA nanostructures (TDNs) are molecules with a pyramidal structure formed by folding four single strands of DNA based on the principle of base pairing. Although DNA has polyanionic properties
the special spatial structure of TDNs allows them to penetrate the cell membrane without the aid of transfection agents in a caveolin-dependent manner and enables them to participate in the regulation of cellular processes without obvious toxic side effects. Because of their stable spatial structure
TDNs resist the limitations imposed by nuclease activity and innate immune responses to DNA. In addition
TDNs have good editability and biocompatibility
giving them great advantages for biomedical applications. Previous studies have found that TDNs have a variety of biological properties
including promoting cell migration
proliferation and differentiation
as well as having anti-inflammatory
antioxidant
anti-infective and immune regulation capabilities. Moreover
we confirmed that TDNs can promote the regeneration and repair of skin
blood vessels
muscles and bone tissues. Based on these findings
we believe that TDNs have broad prospects for application in wound repair and regeneration. This article reviews recent progress in TDN research and its applications.
关键词
Keywords
Tetrahedral DNA nanostructuresWound treatmentInjury repairInjury regenerationTissue regeneration
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