Roles of the fibroblast growth factor signal transduction system in tissue injury repair

Keyang Chen; Zhiheng Rao; Siyang Dong; Yajing Chen; Xulan Wang; Yongde Luo; Fanghua Gong; Xiaokun Li

doi:10.1093/burnst/tkac005

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Roles of the fibroblast growth factor signal transduction system in tissue injury repair

更新时间：2022-06-09

- Roles of the fibroblast growth factor signal transduction system in tissue injury repair
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
  
  1. School of Pharmaceutical Sciences
  2. Wenzhou Medical University
  3. Department of neurology
  4. The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
  5. Research Units of Clinical Translation of Cell Growth Factors and Diseases Research
  6. Department of breast surgery
  7. The First Affiliated Hospital of Wenzhou Medical University
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac005
  CLC：
- Published：2022，
  
  Published Online：23 March 2022，
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Keyang Chen, Zhiheng Rao, Siyang Dong, Yajing Chen, Xulan Wang, Yongde Luo, Fanghua Gong, Xiaokun Li, Roles of the fibroblast growth factor signal transduction system in tissue injury repair, Burns & Trauma, Volume 10, 2022, tkac005, https://doi.org/10.1093/burnst/tkac005
DOI：

Keyang Chen, Zhiheng Rao, Siyang Dong, Yajing Chen, Xulan Wang, Yongde Luo, Fanghua Gong, Xiaokun Li, Roles of the fibroblast growth factor signal transduction system in tissue injury repair, Burns & Trauma, Volume 10, 2022, tkac005, https://doi.org/10.1093/burnst/tkac005 DOI：

摘要

Abstract

Following injury

tissue autonomously initiates a complex repair process

resulting in either partial recovery or regeneration of tissue architecture and function in most organisms. Both the repair and regeneration processes are highly coordinated by a hierarchy of interplay among signal transduction pathways initiated by different growth factors

cytokines and other signaling molecules under normal conditions. However

under chronic traumatic or pathological conditions

the reparative or regenerative process of most tissues in different organs can lose control to different extents

leading to random

incomplete or even flawed cell and tissue reconstitution and thus often partial restoration of the original structure and function

accompanied by the development of fibrosis

scarring or even pathogenesis that could cause organ failure and death of the organism. Ample evidence suggests that the various combinatorial fibroblast growth factor (FGF) and receptor signal transduction systems play prominent roles in injury repair and the remodeling of adult tissues in addition to embryonic development and regulation of metabolic homeostasis. In this review

we attempt to provide a brief update on our current understanding of the roles

the underlying mechanisms and clinical application of FGFs in tissue injury repair.

关键词

Keywords

Tissue injuryRepairRegenerationCell growthFibroblast growth factorSignal transduction

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