The clinical effectiveness and safety of using epidermal growth factor, fibroblast growth factor and granulocyte-macrophage colony stimulating factor as therapeutics in acute skin wound healing: a systematic review and meta-analysis
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
1. Department of Burn and Plastic Surgery, Department of Wound Repair, Shenzhen Institute of Translational Medicine
2. Shenzhen University
3. School of Public Health and Management, Chongqing Medical University
4. The First Affiliated Hospital, Sun Yat-sen University
5. Research Center for Wound Repair and Tissue Regeneration
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac002
CLC：Published：2022，
Published Online：7 March 2022，
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Yating Wei, Jiangfeng Li, Yao Huang, Xun Lei, Lijun Zhang, Meifang Yin, Jiawen Deng, Xiaoyan Wang, Xiaobing Fu, Jun Wu, The clinical effectiveness and safety of using epidermal growth factor, fibroblast growth factor and granulocyte-macrophage colony stimulating factor as therapeutics in acute skin wound healing: a systematic review and meta-analysis, Burns & Trauma, Volume 10, 2022, tkac002, https://doi.org/10.1093/burnst/tkac002
Yating Wei, Jiangfeng Li, Yao Huang, Xun Lei, Lijun Zhang, Meifang Yin, Jiawen Deng, Xiaoyan Wang, Xiaobing Fu, Jun Wu, The clinical effectiveness and safety of using epidermal growth factor, fibroblast growth factor and granulocyte-macrophage colony stimulating factor as therapeutics in acute skin wound healing: a systematic review and meta-analysis, Burns & Trauma, Volume 10, 2022, tkac002, https://doi.org/10.1093/burnst/tkac002 DOI：
摘要
Abstract
BackgroundPromoting wound healing is crucial to restore the vital barrier function of injured skin. Growth factor products including epidermal growth factor (EGF)
fibroblast growth factor (FGF) and granulocyte-macrophage colony stimulating factor (GM-CSF) have been used for decades although no systematic evaluation exists regarding their effectiveness and safety issues in treating acute skin wounds. This has resulted in a lack of guidelines and standards for proper application regimes. Therefore
this systematic review and meta-analysis was performed to critically evaluate the effectiveness and safety of these growth factors on skin acute wounds and provide guidelines for application regimes.MethodsWe searched PubMed/Medline (1980–2020)
Cochrane Library (1980–2020)
Cochrane CENTRAL (from establishment to 2020)
ClinicalTrials.gov (from establishment to 2020)
Chinese Journal Full-text Database (CNKI
1994–2020)
China Biology Medicine disc (CBM
1978–2019)
Chinese Scientific Journal Database (VIP
1989–2020) and Wanfang Database (WFDATA
1980–2019). Randomized controlled trials (RCTs)
quasi-RCTs and controlled clinical trials treating patients with acute skin wounds from various causes and with those available growth factors were included.ResultsA total of 7573 papers were identified through database searching; 229 papers including 281 studies were kept after final screening. Administering growth factors significantly shortened the healing time of acute skin wounds
including superficial burn injuries [mean difference (MD) = −3.02; 95% confidence interval (CI):−3.31 ~ −2.74; p < 0.00001]
deep burn injuries (MD = −5.63; 95% CI:−7.10 ~ −4.17; p < 0.00001)
traumata and surgical wounds (MD = −4.50; 95% CI:−5.55 ~ −3.44; p < 0.00001). Growth factors increased the healing rate of acute skin wounds and decreased scar scores. The incidence of adverse reactions was lower in the growth factor treatment group than in the non-growth factor group.ConclusionsThe studied growth factors not only are effective and safe for managing acute skin wounds
but also accelerate their healing with no severe adverse reactions.
关键词
Keywords
Growth factorsSkin woundsMeta-analysisWound healing
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