Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing

Tingting Weng; Jialiang Wang; Min Yang; Wei Zhang; Pan Wu; Chuangang You; Chunmao Han; Xingang Wang

doi:10.1093/burnst/tkab049

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Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing

更新时间：2022-06-09

- Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
  
  1. Department of Burns & Wound Care Centre
  2. the Second Affiliated Hospital of Zhejiang University School of Medicine
  3. Key Laboratory of The Diagnosis and Treatment of Severe Trauma and Burn of Zhejiang Province
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkab049
  CLC：
- Published：2022，
  
  Published Online：22 March 2022，
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Tingting Weng, Jialiang Wang, Min Yang, Wei Zhang, Pan Wu, Chuangang You, Chunmao Han, Xingang Wang, Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing, Burns & Trauma, Volume 10, 2022, tkab049, https://doi.org/10.1093/burnst/tkab049
DOI：

Tingting Weng, Jialiang Wang, Min Yang, Wei Zhang, Pan Wu, Chuangang You, Chunmao Han, Xingang Wang, Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing, Burns & Trauma, Volume 10, 2022, tkab049, https://doi.org/10.1093/burnst/tkab049 DOI：

摘要

Abstract

Dermal substitutes provide a template for dermal regeneration and reconstruction. They constitutes an ideal clinical treatment for deep skin defects. However

rapid vascularization remains as a major hurdle to the development and application of dermal substitutes. Several bioactive factors play an important regulatory role in the process of angiogenesis and an understanding of the mechanism of achieving their effective delivery and sustained function is vital. Nanomaterials have great potential for tissue engineering. Effective delivery of bioactive factors (including growth factors

peptides and nucleic acids) by nanomaterials is of increasing research interest. This paper discusses the process of dermal substitute angiogenesis and the roles of related bioactive factors in this process. The application of nanomaterials for the delivery of bioactive factors to enhance angiogenesis and accelerate wound healing is also reviewed. We focus on new systems and approaches for delivering bioactive factors for enhancing angiogenesis in dermal substitutes.

关键词

Keywords

NanomaterialsBioactive factorsDermal substituteAngiogenesisWound healingRegenerationTissue engineeringVascularization

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