Role of copper nanoparticles in wound healing for chronic wounds: literature review
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
1. Escuela de Enfermería
2. Programa de Doctorado en Ciencias Morfológicas
3. Escuela de Tecnología Médica
4. Departamento de Ciencias Preclínicas
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkab047
CLC：Published：2022，
Published Online：21 January 2022，
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Jessica Salvo, Cristian Sandoval, Role of copper nanoparticles in wound healing for chronic wounds: literature review, Burns & Trauma, Volume 10, 2022, tkab047, https://doi.org/10.1093/burnst/tkab047
摘要
Abstract
Chronic wounds are defined as wounds that fail to proceed through the normal phases of wound healing in an orderly and timely manner. The most common and inevitable impairment to wound healing is the installation of an infection
usually in the case of chronic wounds. Therefore
the objective of the present review was to identify the importance of copper nanoparticles in dressings for wound healing. Nanoparticles such as silver
gold and copper combat infectious processes through the inhibition of protein synthesis
peroxidation of the cell membrane and destroying the nucleic acids of bacteria and viruses. Among bioactive nanoparticles
copper plays a complex role in various cells
it modulates several cytokines and growth factor mechanisms of action and is essentially involved in all stages of the wound healing process. More importantly
copper plays a key role in skin regeneration and angiogenesis and accelerates the healing process through induction of vascular endothelial growth factor (VEGF) and angiogenesis by hypoxia-induced factor-1-alpha (HIF-1α) action where copper enhances HIF-1α expression and HIF-1α binding to the critical motifs in the promoter and putative enhancer regions of HIF-1-regulated genes.
关键词
Keywords
AngiogenesisAntimicrobialNanoparticlesRegenerationWound healingChronic woundVEGFHIF-1α
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