Senescence in chronic wounds and potential targeted therapies

Xuerong Wei; Minxiong Li; Zijun Zheng; Jun Ma; Yanbin Gao; Lianglong Chen; Yujie Peng; Shengxiang Yu; Lei Yang

doi:10.1093/burnst/tkab045

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Senescence in chronic wounds and potential targeted therapies

更新时间：2022-06-09

- Senescence in chronic wounds and potential targeted therapies
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
  
  1. Department of Burns
  2. Southern Medical University
  3. Department of Plastic and Reconstructive Surgery
  4. Shanghai JiaoTong University School of Medicine
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkab045
  CLC：
- Published：2022，
  
  Published Online：17 February 2022，
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Xuerong Wei, Minxiong Li, Zijun Zheng, Jun Ma, Yanbin Gao, Lianglong Chen, Yujie Peng, Shengxiang Yu, Lei Yang, Senescence in chronic wounds and potential targeted therapies, Burns & Trauma, Volume 10, 2022, tkab045, https://doi.org/10.1093/burnst/tkab045
DOI：

Xuerong Wei, Minxiong Li, Zijun Zheng, Jun Ma, Yanbin Gao, Lianglong Chen, Yujie Peng, Shengxiang Yu, Lei Yang, Senescence in chronic wounds and potential targeted therapies, Burns & Trauma, Volume 10, 2022, tkab045, https://doi.org/10.1093/burnst/tkab045 DOI：

摘要

Abstract

Chronic wounds (e.g. diabetic wounds

pressure wounds

vascular ulcers

etc.) do not usually heal in a timely and orderly manner but rather last for years and may lead to irreversible adverse events

resulting in a substantial financial burden for patients and society. Recently

a large amount of evidence has proven that cellular senescence has a crucial influence on chronic nonhealing wounds. As a defensive mechanism

cell senescence is a manner of cell-cycle arrest with increased secretory phenotype to resist death

preventing cells from stress-induced damage in cancer and noncancer diseases. A growing amount of research has advanced the perception of cell senescence in various chronic wounds and focuses on pathological and physiological processes and therapies targeting senescent cells. However

previous reviews have failed to sum up novel understandings of senescence in chronic wounds and emerging strategies targeting senescence. Herein

we discuss the characteristics and mechanisms of cellular senescence and the link between senescence and chronic wounds as well as some novel antisenescence strategies targeting other diseases that may be applied for chronic wounds.

关键词

Keywords

Chronic woundsSenescenceSenolyticsTargeted therapiesDiabetic woundPressure woundVascular ulcer

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