3D-bioprinted microenvironments for sweat gland regeneration
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
1. Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College
2. PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury
3. Department of Cardiac Surgery
4. Guangdong Academy of Medical Sciences
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkab044
CLC：Published：2022，
Published Online：21 January 2022，
扫 描 看 全 文
Wei Song, Bin Yao, Dongzhen Zhu, Yijie Zhang, Zhao Li, Sha Huang, Xiaobing Fu, 3D-bioprinted microenvironments for sweat gland regeneration, Burns & Trauma, Volume 10, 2022, tkab044, https://doi.org/10.1093/burnst/tkab044
摘要
Abstract
The development of 3D bioprinting in recent years has provided new insights into the creation of in vitro microenvironments for promoting stem cell-based regeneration. Sweat glands (SGs) are mainly responsible for thermoregulation and are a highly differentiated organ with limited regenerative ability. Recent studies have focused on stem cell-based therapies as strategies for repairing SGs after deep dermal injury. In this review
we highlight the recent trend in 3D bioprinted native-like microenvironments and emphasize recent advances in functional SG regeneration using this technology. Furthermore
we discuss five possible regulatory mechanisms in terms of biochemical factors and structural and mechanical cues from 3D bioprinted microenvironments
as well as the most promising regulation from neighbor cells and the vascular microenvironment.
关键词
Keywords
3D bioprintingMicroenvironmentSweat glands regenerationStem cells
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