Ventilation practices in burn patients—an international prospective observational cohort study

Gerie J Glas; Janneke Horn; Markus W Hollmann; Benedikt Preckel; Kirsten Colpaert; Manu Malbrain; Ary Serpa Neto; Karim Asehnoune; Marcello Gamma de Abreu; Ignacio Martin-Loeches; Paolo Pelosi; Folke Sjöberg; Jan M Binnekade; Berry Cleffken; Nicole P Juffermans; Paul Knape; Bert G Loef; David P Mackie; Perenlei Enkhbaatar; Nadia Depetris; Anders Perner; Eva Herrero; Lucia Cachafeiro; Marc Jeschke; Jeffrey Lipman; Matthieu Legrand; Johannes Horter; Athina Lavrentieva; Alex Kazemi; Anne Berit Guttormsen; Frederik Huss; Mark Kol; Helen Wong; Therese Starr; Luc De Crop; Wilson de Oliveira Filho; João Manoel Silva Junior; Cintia M C Grion; Marjorie Burnett; Frederik Mondrup; Francois Ravat; Mathieu Fontaine; Renan Le Floch; Mathieu Jeanne; Morgane Bacus; Maïté Chaussard; Marcus Lehnhardt; Bassem Daniel Mikhail; Jochen Gille; Aidan Sharkey; Nicole Trommel; Auke C Reidinga; Nadine Vieleers; Anna Tilsley; Henning Onarheim; Maria Teresa Bouza; Alexander Agrifoglio; Filip Fredén; Tina Palmieri; Lynda E Painting; Marcus J Schultz; LAMiNAR investigators

doi:10.1093/burnst/tkab034

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Ventilation practices in burn patients—an international prospective observational cohort study

更新时间：2022-06-14

- Ventilation practices in burn patients—an international prospective observational cohort study
- Burns & Trauma Vol. 9, Issue 1, (2021)
- 作者机构：
  
  1. Academic Medical Center
  2. Department of Anaesthesia and Intensive Therapy Medical University of Lublin Aleje Racklawickie
  3. AZ JAN PALFIJN GENT Watersportlaan
  4. ABC Medical School
  5. Australian and New Zealand Intensive Care Research Centre. Monash University
  6. St-Louis- Lariboisière, APHP,GH
  7. Service d'Anesthésie Réanimation Chirurgicale
  8. University Hospital Carl Gustav Carus
  9. St James University Hospital
  10. University of Genoa
  11. Linköping University Hospital
  12. Maasstad Hospital
  13. Red Cross Hospital
  14. Martini Hospital
  15. University of Texas Medical Branch
  16. Turin CTO Burn Center
  17. Rigshospitalet
  18. La Paz University Hospital
  19. Ross Tilley Burn Centre
  20. Royal Brisbane and Women’s Hospital, Queensland University
  21. Hopital Roger Salengro, CHRU Lille
  22. BG Klinik Ludwigshafen
  23. Papanikoalou Hospital
  24. Middlemore Hospital
  25. Haukeland University Hospital
  26. Uppsala University Hospital
  27. Concord Repatriation General Hospital NSW
  28. Ziekenhuis Netwerk Antwerpen–Stuivenberg
  29. Hospital e Pronto Socorro 28 de Agosto
  30. Universidade de Sao Paulo
  31. Universidade Estadual de Londrina
  32. Sunnybrook Health Sciences Centre
  33. CHU Lyon St Luc
  34. CHU Nantes Service dánesthesie reanimation chirugicale
  35. Saint-Louis Hospital
  36. BG University Hospital Bergmannsheil
  37. St George Leipzig
  38. . James Hospital,St
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkab034
  CLC：
- Published：2021，
  
  Published Online：16 December 2021，
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Gerie J Glas, Janneke Horn, Markus W Hollmann, Benedikt Preckel, Kirsten Colpaert, Manu Malbrain, Ary Serpa Neto, Karim Asehnoune, Marcello Gamma de Abreu, Ignacio Martin-Loeches, Paolo Pelosi, Folke Sjöberg, Jan M Binnekade, Berry Cleffken, Nicole P Juffermans, Paul Knape, Bert G Loef, David P Mackie, Perenlei Enkhbaatar, Nadia Depetris, Anders Perner, Eva Herrero, Lucia Cachafeiro, Marc Jeschke, Jeffrey Lipman, Matthieu Legrand, Johannes Horter, Athina Lavrentieva, Alex Kazemi, Anne Berit Guttormsen, Frederik Huss, Mark Kol, Helen Wong, Therese Starr, Luc De Crop, Wilson de Oliveira Filho, João Manoel Silva Junior, Cintia M C Grion, Marjorie Burnett, Frederik Mondrup, Francois Ravat, Mathieu Fontaine, Renan Le Floch, Mathieu Jeanne, Morgane Bacus, Maïté Chaussard, Marcus Lehnhardt, Bassem Daniel Mikhail, Jochen Gille, Aidan Sharkey, Nicole Trommel, Auke C Reidinga, Nadine Vieleers, Anna Tilsley, Henning Onarheim, Maria Teresa Bouza, Alexander Agrifoglio, Filip Fredén, Tina Palmieri, Lynda E Painting, Marcus J Schultz, LAMiNAR investigators, Ventilation practices in burn patients—an international prospective observational cohort study, Burns & Trauma, Volume 9, 2021, tkab034, https://doi.org/10.1093/burnst/tkab034
DOI：

Gerie J Glas, Janneke Horn, Markus W Hollmann, Benedikt Preckel, Kirsten Colpaert, Manu Malbrain, Ary Serpa Neto, Karim Asehnoune, Marcello Gamma de Abreu, Ignacio Martin-Loeches, Paolo Pelosi, Folke Sjöberg, Jan M Binnekade, Berry Cleffken, Nicole P Juffermans, Paul Knape, Bert G Loef, David P Mackie, Perenlei Enkhbaatar, Nadia Depetris, Anders Perner, Eva Herrero, Lucia Cachafeiro, Marc Jeschke, Jeffrey Lipman, Matthieu Legrand, Johannes Horter, Athina Lavrentieva, Alex Kazemi, Anne Berit Guttormsen, Frederik Huss, Mark Kol, Helen Wong, Therese Starr, Luc De Crop, Wilson de Oliveira Filho, João Manoel Silva Junior, Cintia M C Grion, Marjorie Burnett, Frederik Mondrup, Francois Ravat, Mathieu Fontaine, Renan Le Floch, Mathieu Jeanne, Morgane Bacus, Maïté Chaussard, Marcus Lehnhardt, Bassem Daniel Mikhail, Jochen Gille, Aidan Sharkey, Nicole Trommel, Auke C Reidinga, Nadine Vieleers, Anna Tilsley, Henning Onarheim, Maria Teresa Bouza, Alexander Agrifoglio, Filip Fredén, Tina Palmieri, Lynda E Painting, Marcus J Schultz, LAMiNAR investigators, Ventilation practices in burn patients—an international prospective observational cohort study, Burns & Trauma, Volume 9, 2021, tkab034, https://doi.org/10.1093/burnst/tkab034 DOI：

摘要

Abstract

BackgroundIt is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28).MethodsThis is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation. Low tidal volume (VT) was defined as VT ≤ 8 mL/kg predicted body weight (PBW). Levels of positive end-expiratory pressure (PEEP) and maximum airway pressures were collected. The association between VT and VFD-28 was analyzed using a competing risk model. Ventilation settings were presented for all patients

focusing on the first day of ventilation. We also compared ventilation settings between patients with and without inhalation trauma.ResultsA total of 160 patients from 28 ICUs in 16 countries were included. Low VT was used in 74% of patients

median VT size was 7.3 [interquartile range (IQR) 6.2–8.3] mL/kg PBW and did not differ between patients with and without inhalation trauma (p = 0.58). Median VFD-28 was 17 (IQR 0–26)

without a difference between ventilation with low or high VT (p = 0.98). All patients were ventilated with PEEP levels ≥5 cmH2O; 80% of patients had maximum airway pressures <30 cmH2O.ConclusionIn this international cohort study we found that lung-protective ventilation is used in the majority of burn patients

irrespective of the presence of inhalation trauma. Use of low VT was not associated with a reduction in VFD-28.Trial registrationClinicaltrials.gov NCT02312869. Date of registration: 9 December 2014.

关键词

Keywords

Mechanical ventilationInhalation traumaLung-protectiveCritical care

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