Combination of ablative fractional carbon dioxide laser and platelet-rich plasma treatment to improve hypertrophic scars: a retrospective clinical observational study

Zhanzhan Dai; Xiaozhen Lou; Tuo Shen; Yu Sun; Yongqiang Xiao; Xingfeng Zheng; Xuexin Wang; Yu Peng; Yukun Guo; Yibin Guo; Jiannan Wen; He Fang; Bing Ma; Zhaofan Xia

doi:10.1093/burnst/tkab016

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Combination of ablative fractional carbon dioxide laser and platelet-rich plasma treatment to improve hypertrophic scars: a retrospective clinical observational study

更新时间：2022-06-14

- Combination of ablative fractional carbon dioxide laser and platelet-rich plasma treatment to improve hypertrophic scars: a retrospective clinical observational study
- Burns & Trauma Vol. 9, Issue 1, (2021)
- 作者机构：
  
  1. Department of Burn Surgery
  2. Research Unit of key techniques for treatment of burns and combined burns and trauma injury, Chinese Academy of Medical Sciences
  3. Department of Burn and Plastic Surgery, the 970th Hospital of People's Liberation Army
  4. Department of Health Statistics, the Naval Medical University
  5. First Resident Outpatient Department of Northern Theater General Hospital
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkab016
  CLC：
- Published：2021，
  
  Published Online：28 July 2021，
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Zhanzhan Dai, Xiaozhen Lou, Tuo Shen, Yu Sun, Yongqiang Xiao, Xingfeng Zheng, Xuexin Wang, Yu Peng, Yukun Guo, Yibin Guo, Jiannan Wen, He Fang, Bing Ma, Zhaofan Xia, Combination of ablative fractional carbon dioxide laser and platelet-rich plasma treatment to improve hypertrophic scars: a retrospective clinical observational study, Burns & Trauma, Volume 9, 2021, tkab016, https://doi.org/10.1093/burnst/tkab016
DOI：

Zhanzhan Dai, Xiaozhen Lou, Tuo Shen, Yu Sun, Yongqiang Xiao, Xingfeng Zheng, Xuexin Wang, Yu Peng, Yukun Guo, Yibin Guo, Jiannan Wen, He Fang, Bing Ma, Zhaofan Xia, Combination of ablative fractional carbon dioxide laser and platelet-rich plasma treatment to improve hypertrophic scars: a retrospective clinical observational study, Burns & Trauma, Volume 9, 2021, tkab016, https://doi.org/10.1093/burnst/tkab016 DOI：

摘要

Abstract

BackgroundHypertrophic scars are one of the main complications that affect the quality of life of patients after burns. Many methods have been shown to be effective in the treatment of hypertrophic scars

such as ablative fractional CO2 laser (AFCL) and platelet-rich plasma (PRP). However

there are few studies on the effect of the combined application of these measures. The purpose of this study was to explore the therapeutic effect of AFCL combined with PRP on hypertrophic burn scars.MethodsA retrospective clinical observation study was conducted on 50 patients with hypertrophic burn scars. The AFCL+PRP group included 31 patients who received AFCL combined with PRP treatment; the AFCL group included 19 patients who received AFCL treatment only. The University of North Carolina 4P Scar Scale (UNC4P) and the Vancouver Scar Scale (VSS) scores that were collected before each treatment were used as indicators of the effectiveness of the previous treatment. The scores recorded at the second

fourth and seventh months were analysed.ResultsThe demographic data of the 2 groups were not significantly different. Before treatment

there was no difference in the UNC4P and VSS scores between the 2 groups. There was a significant decline in the UNC4P and VSS total scores over 6 months in both groups (p < 0.05) and scores in the 2 groups were comparable after 3 and 6 months (p < 0.05). UNC4P scores in the AFCL+PRP group decreased from a mean of 8.26 to 2.61 (p < 0.05) with a concomitant drop in VSS scores from a mean of 11.74 to 6.06 (p < 0.01). In the AFCL group UNC4P and VSS scores decreased from 7.68 to 4.63 (p < 0.05) and from 10.89 to 8.16 (p < 0.05)

respectively. The sub-items of these 2 assessments were analysed and the results suggest that AFCL combined with PRP can comprehensively improve scarring.ConclusionsThis study shows that PRP is an effective adjunct for AFCL in the treatment of hypertrophic burn scars and that the combination of PRP and AFCL proved to be more useful than AFCL alone. This combination may be a new and effective clinical practice for the treatment of scars. However

larger and higher-level clinical studies are still needed to determine its efficacy and possible mechanisms.

关键词

Keywords

Ablative fractional carbon dioxide laserPlatelet-rich plasmaHypertrophic scars

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