3D printing of functional nerve guide conduits
- Burns & Trauma Vol. 9, Issue 1, (2021)
- 作者机构：
1. State Key Laboratory of Biotherapy and Cancer Center
2. Sichuan University
3. Department of Ophthalmology
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkab011
CLC：Published：2021，
Published Online：7 May 2021，
扫 描 看 全 文
Yulan Huang, Wenbi Wu, Haofan Liu, Yuwen Chen, Bo Li, Zhiyuan Gou, Xun Li, Maling Gou, 3D printing of functional nerve guide conduits, Burns & Trauma, Volume 9, 2021, tkab011, https://doi.org/10.1093/burnst/tkab011
摘要
Abstract
Nerve guide conduits (NGCs)
as alternatives to nerve autografts and allografts
have been widely explored as an advanced tool for the treatment of peripheral nerve injury. However
the repairing efficiency of NGCs still needs significant improvements. Functional NGCs that provide a more favorable microenvironment for promoting axonal elongation and myelination are of great importance. In recent years
3D printing technologies have been widely applied in the fabrication of customized and complex constructs
exhibiting great potential for tissue engineering applications
especially for the construction of functional NGCs. In this review
we introduce the 3D printing technologies for manufacturing functional NGCs
including inkjet printing
extrusion printing
stereolithography-based printing and indirect printing. Further
we summarize the current methods and strategies for constructing functional NGCs
such as designing special conduit architectures
using appropriate materials and co-printing with different biological cues. Finally
the challenges and prospects for construction of functional NGCs are also presented.
关键词
Keywords
Nerve guide conduitsFunctionalizationPeripheral nerve repair3D printing
references
1.Rigoni M, Negro S. Signals orchestrating peripheral nerve repair. Cell 2020;9.
2.Carvalho CR, Silva-Correia J, Oliveira JM, Reis RL. Nanotechnology in peripheral nerve repair and reconstruction. Adv Drug Deliv Rev 2019;148:308–43.
3.Mukhatyar V, Karumbaiah L, Yeh J, Bellamkonda R. Tissue Engineering Strategies Designed to Realize the Endogenous Regenerative Potential of Peripheral Nerves. Advanced Materials:NA-NA, 2009.
4.Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA et al. A systems-level analysis of the peripheral nerve intrinsic axonal growth program. Neuron 2016;89:956–70.
5.Griffin JW, Hogan MV, Chhabra AB, Deal DN. Peripheral nerve repair and reconstruction. J Bone Joint Surg Am 2013;95:2144–51.
6.Raza C, Riaz HA, Anjum R, Shakeel NA. Repair strategies for injured peripheral nerve: review. Life Sci 2020;243.
7.Deumens R, Bozkurt A, Meek MF, Marcus MA, Joosten EA, Weis J et al. Repairing injured peripheral nerves: bridging the gap. Prog Neurobiol 2010;92:245–76.
8.Yin J, Zhang DM, Xiang Y, Wei P, Yang ZY, Wang ZH et al. The influence of cross-sectional morphology on the compressive resistance of polymeric nerve conduits. Polymer 2018;148:93–100.
9.Kehoe S, Zhang XF, Boyd D. FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy. Injury 2012;43:553–72.
10.Kornfeld T, Vogt PM, Radtke C. Nerve grafting for peripheral nerve injuries with extended defect sizes. Wien Med Wochenschr 2019;169:240–51.
11.Bellamkonda RV. Peripheral nerve regeneration: An opinion on channels, scaffolds and anisotropy. Biomaterials 2006;27:3515–8.
12.Zhang X, Qu W, Li D, Shi K, Li R, Han Y et al. Functional polymer-based nerve guide conduits to promote peripheral nerve regeneration. Adv Mater Interfaces 2020;7.
13.Manoukian OS, Baker JT, Rudraiah S, Arul MR, Vella AT, Domb AJ et al. Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration. J Control Release 2020;317:78–95.
14.Ma X, Liu J, Zhu W, Tang M, Lawrence N, Yu C et al. 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Adv Drug Deliv Rev 2018;132:235–51.
15.Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol 2014;32:773–85.
16.Kang HW, Lee SJ, Ko IK, Kengla C, Yoo JJ, Atala A. A 3D bioprinting system to produce human-scale tissue constructs with structural integrity. Nat Biotechnol 2016;34:312–9.
17.Suo HR, Li L, Zhang CX, Yin J, Xu KD, Liu JY et al. Glucosamine-grafted methacrylated gelatin hydrogels as potential biomaterials for cartilage repair. Journal of Biomedical Materials Research Part B-Applied Biomaterials 2020;108:990–9.
18.Grigoryan B, Paulsen SJ, Corbett DC, Sazer DW, Fortin CL, Zaita AJ et al. BIOMEDICINE multivascular networks and functional intravascular topologies within biocompatible hydrogels. Science 2019;364: 458-+.
19.Noor N, Shapira A, Edri R, Gal I, Wertheim L, Dvir T. 3D printing of personalized thick and Perfusable cardiac patches and hearts. Adv Sci 2019;6.
20.Maiti B, Diaz Diaz D. 3D printed polymeric hydrogels for nerve regeneration. Polymers 2018;10.
21.Ford S, Despeisse M. Additive manufacturing and sustainability: an exploratory study of the advantages and challenges. J Clean Prod 2016;137:1573–87.
22.Wang X, Jiang M, Zhou ZW, Gou JH, Hui D. 3D printing of polymer matrix composites: a review and prospective. Composites Part B-Engineering 2017;110:442–58.
23.Sarker M, Naghieh S, McInnes AD, Schreyer DJ, Chen X. Strategic design and fabrication of nerve guidance conduits for peripheral nerve regeneration. Biotechnol J 2018;13.
24.Xue JJ, Wu T, Dai YQ, Xia YN. Electrospinning and electrospun nanofibers: methods, materials, and applications. Chem Rev 2019;119:5298–415.
25.Ling L, Yang Y. Exploration on creative product customization design based on 3D printing technology research. Appl Mech Mater 2015;709:509–12.
26.Ghosh U, Ning S, Wang Y, Kong YL. Addressing unmet clinical needs with 3D printing technologies. Adv Healthc Mater 2018;7.
27.Rengier F, Mehndiratta A, von Tengg-Kobligk H, Zechmann CM, Unterhinninghofen R, Kauczor HU et al. 3D printing based on imaging data: review of medical applications. Int J Comput Assist Radiol Surg 2010;5:335–41.
28.Felix HM, Rosenbush KA, Lannen AM, Pooley RA, Siegel JL, Brown BL et al. Creation of an optic nerve sheath diameter ultrasound model for NeuroICU education. Mil Med Res 2020;7.
29.Gu Q, Zhu H, Li J, Li X, Hao J, Wallace GG et al. Three-dimensional bioprinting speeds up smart regenerative medicine. Natl Sci Rev 2016;3:331–44.
30.Yu X, Zhang T, Li Y. 3D printing and bioprinting nerve conduits for neural tissue engineering. Polymers 2020;12.
31.Radulescu D, Dhar S, Young CM, Taylor DW, Trost H-J, Hayes DJ et al. Tissue engineering scaffolds for nerve regeneration manufactured by ink-jet technology. Mater Sci Eng C 2007;27:534–9.
32.Tse C, Whiteley R, Yu T, Stringer J, MacNeil S, Haycock JW et al. Inkjet printing Schwann cells and neuronal analogue NG108-15 cells. Biofabrication 2016;8.
33.Cui H, Nowicki M, Fisher JP, Zhang LG. 3D bioprinting for organ regeneration. Adv Healthc Mater 2017;6.
34.Wang R, Wang Y, Yao B, Hu T, Li Z, Liu Y et al. Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment. Burns & Trauma 2019;7.
35.Johnson BN, Lancaster KZ, Zhen G, He J, Gupta MK, Kong YL et al. 3D printed anatomical nerve regeneration pathways. Adv Funct Mater 2015;25:6205–17.
36.Jakus AE, Secor EB, Rutz AL, Jordan SW, Hersam MC, Shah RN. Three-dimensional printing of high-content graphene scaffolds for electronic and biomedical applications. ACS Nano 2015;9:4636–48.
37.Wu Z, Li Q, Xie S, Shan X, Cai Z. In vitro and in vivo biocompatibility evaluation of a 3D bioprinted gelatin-sodium alginate/rat Schwann-cell scaffold. Korean J Couns Psychother 2020;109:110530–0.
38.Guo G, Zhu Y, Wu Z, Ji H, Lu X, Zhou Y et al. Circulating monocytes accelerate acute liver failure by IL-6 secretion in monkey. J Cell Mol Med 2018;22:4056–67.
39.Soltan N, Ning L, Mohabatpour F, Papagerakis P, Printability CX. Cell viability in bioprinting alginate Dialdehyde-Gelatin scaffolds. ACS Biomater Sci Eng 2019;5:2976–87.
40.Ligon SC, Liska R, Stampfl J, Gurr M, Muelhaupt R. Polymers for 3D printing and customized additive manufacturing. Chem Rev 2017;117:10212–90.
41.Pateman CJ, Harding AJ, Glen A, Taylor CS, Christmas CR, Robinson PP et al. Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair. Biomaterials 2015;49:77–89.
42.Singh A, Asikainen S, Teotia AK, Shiekh PA, Huotilainen E, Qayoom I et al. Biomimetic Photocurable three-dimensional printed nerve guidance channels with aligned Cryomatrix lumen for peripheral nerve regeneration. ACS Appl Mater Interfaces 2018;10:43327–42.
43.Lee SJ, Esworthy T, Stake S, Miao S, Zuo YY, Harris BT et al. Advances in 3D bioprinting for neural tissue engineering. Advanced Biosystems 2018;2.
44.Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H et al. Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Mater Today 2018;21:951–9.
45.Tao J, Zhang J, Du T, Xu X, Deng X, Chen S et al. Rapid 3D printing of functional nanoparticle-enhanced conduits for effective nerve repair. Acta Biomater 2019;90:49–59.
46.Hu Y, Wu Y, Gou Z, Tao J, Zhang J, Liu Q et al. 3D-engineering of Cellularized conduits for peripheral nerve regeneration. Sci Rep 2016;6:32184.
47.Tao J, Hu Y, Wang S, Zhang J, Liu X, Gou Z et al. A 3D-engineered porous conduit for peripheral nerve repair. Sci Rep 2017;7:46038.
48.Mueller M, Becher J, Schnabelrauch M, Zenobi-Wong M. Printing Thermoresponsive reverse Molds for the creation of patterned two-component hydrogels for 3D cell culture. Jove-Journal of Visualized Experiments 2013;77.
49.Naghieh S, Sarker MD, Abelseth E, Chen X. Indirect 3D bioprinting and characterization of alginate scaffolds for potential nerve tissue engineering applications. J Mech Behav Biomed Mater 2019;93:183–93.
50.Xu T, Gregory CA, Molnar P, Cui X, Jalota S, Bhaduri SB et al. Viability and electrophysiology of neural cell structures generated by the inkjet printing method. Biomaterials 2006;27:3580–8.
51.Zhang AP, Qu X, Soman P, Hribar KC, Lee JW, Chen S et al. Rapid fabrication of complex 3D extracellular microenvironments by dynamic optical projection stereolithography. Adv Mater 2012;24:4266–70.
52.Evangelista MS, Perez M, Salibian AA, Hassan JM, Darcy S, Paydar KZ et al. Single-lumen and multi-lumen poly(ethylene glycol) nerve conduits fabricated by Stereolithography for peripheral nerve regeneration in vivo. J Reconstr Microsurg 2015;31:327–35.
53.Lee S-J, Nowicki M, Harris B, Zhang LG. Fabrication of a highly aligned neural scaffold via a table top Stereolithography 3D printing and electrospinning. Tissue Eng Part A 2017;23: 491-+.
54.Singh D, Harding AJ, Albadawi E, Boissonade FM, Haycock JW, Claeyssens F. Additive manufactured biodegradable poly (glycerol sebacate methacrylate) nerve guidance conduits. Acta Biomater 2018;78:48–63.
55.Gong H, Fei H, Xu Q, Gou M, Chen HH. 3D-engineered GelMA conduit filled with ECM promotes regeneration of peripheral nerve. J Biomed Mater Res A 2020;108:805–13.
56.Tao J, Liu H, Wu W, Zhang J, Liu S, Zhang J et al. 3D-printed nerve conduits with live platelets for effective peripheral nerve repair. Adv Funct Mater 2020.
57.Wang J, Xiong H, Zhu T, Liu Y, Pan H, Fan C et al. Bioinspired multichannel nerve guidance conduit based on shape memory nanofibers for potential application in peripheral nerve repair. ACS Nano 2020.
58.Sun X, Bai Y, Zhai H, Liu S, Zhang C, Xu Y et al. Devising micro/nano-architectures in multi-channel nerve conduits towards a pro-regenerative matrix for the repair of spinal cord injury. Acta Biomater 2019;86:194–206.
59.Diez-Ahedo R, Mendibil X, Carmen Marquez-Posadas M, Quintana I, Gonzalez F, Javier Rodriguez F et al. UV-casting on Methacrylated PCL for the production of a peripheral nerve implant containing an Array of porous aligned microchannels. Polymers 2020;12.
60.Qian Y, Song J, Zheng W, Zhao X, Ouyang Y, Yuan W et al. 3D manufacture of gold nanocomposite channels facilitates neural differentiation and regeneration. Adv Funct Mater 2018;28.
61.Yao L, de Ruiter GC, Wang H, Knight AM, Spinner RJ, Yaszemski MJ et al. Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit. Biomaterials 2010;31:5789–97.
62.Arcaute K, Mann BK, Wicker RB. Fabrication of off-the-shelf multilumen poly(ethylene glycol) nerve guidance conduits using Stereolithography. Tissue Engineering Part C-Methods 2011;17:27–38.
63.He J, Sun C, Gu Z, Yang Y, Gu M, Xue C et al. Morphology, migration, and transcriptome analysis of Schwann cell culture on butterfly wings with different surface architectures. ACS Nano 2018;12:9660–8.
64.Jiang T, Zhao J, Yu S, Mao Z, Gao C, Zhu Y et al. Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels. Biomaterials 2019;188:130–43.
65.Zhang D, Xu S, Wu S, Gao C. Micropatterned poly (d,l-lactide-co-caprolactone) films entrapped with gelatin for promoting the alignment and directional migration of Schwann cells. J Mater Chem B 2018;6:1226–37.
66.Zhang D, Wu S, Feng J, Duan Y, Xing D, Gao C. Micropatterned biodegradable polyesters clicked with CQAASIKVAV promote cell alignment, directional migration, and neurite outgrowth. Acta Biomater 2018;74:143–55.
67.Zhang DM, Suo HR, Qian J, Yin J, Fu JZ, Huang Y. Physical understanding of axonal growth patterns on grooved substrates: groove ridge crossing versus longitudinal alignment. Bio-Design and Manufacturing 2020;3:348–60.
68.Behbehani M, Glen A, Taylor CS, Schuhmacher A, Claeyssens F, Haycock JW. Pre-clinical evaluation of advanced nerve guide conduits using a novel 3D in vitro testing model. International Journal of Bioprinting 2018;4.
69.Wang ZH, Wu YB, Xiang Y, Kruth MB, Wei P, Dai GL et al. Efficacy of large groove texture on rat sciatic nerve RegenerationIn VivoUsing Polyacrylonitrile nerve conduits. Ann Biomed Eng 2020.
70.Huang C, Ouyang Y, Niu H, He N, Ke Q, Jin X et al. Nerve guidance conduits from aligned nanofibers: improvement of nerve regeneration through longitudinal Nanogrooves on a Fiber surface. ACS Appl Mater Interfaces 2015;7:7189–96.
71.Zhang D, Yao Y, Duan Y, Yu X, Shi H, Nakkala JR et al. Surface-anchored graphene oxide Nanosheets on cell-scale micropatterned poly (d,l-lactide-co-caprolactone) conduits promote peripheral nerve regeneration. ACS Appl Mater Interfaces 2020;12:7915–30.
72.Jiang L-B, Su D-H, Ding S-L, Zhang Q-C, Li Z-F, Chen F-C et al. Salt-assisted toughening of protein hydrogel with controlled degradation for bone regeneration. Adv Funct Mater 2019;29.
73.Vijayavenkataraman S, Kannan S, Cao T, Fuh JYH, Sriram G, Lu WF. 3D-printed PCL/PPy conductive scaffolds as three-dimensional porous nerve guide conduits (NGCs) for peripheral nerve injury repair. Front Bioeng Biotechnol 2019;7.
74.Sun B, Zhou Z, Li D, Wu T, Zheng H, Liu J et al. Polypyrrole-coated poly (l-lactic acid-co-epsilon-caprolactone)/silk fibroin nanofibrous nerve guidance conduit induced nerve regeneration in rat. Materials Science & Engineering C-Materials for Biological Applications 2019;94:190–9.
75.Vijayavenkataraman S. Nerve guide conduits for peripheral nerve injury repair: a review on design, materials and fabrication methods. Acta Biomater 2020;106:54–69.
76.Ning L, Zhu N, Mohabatpour F, Sarker MD, Schreyer DJ, Chen X. Bioprinting Schwann cell-laden scaffolds from low-viscosity hydrogel compositions. J Mater Chem B 2019;7:4538–51.
77.Sun W, Zhang Y, Gregory DA, Jimenez-Franco A, Tomeh MA, Lv S et al. Patterning the neuronal cells via inkjet printing of self-assembled peptides on silk scaffolds. Progress in Natural Science-Materials International 2020;30:686–96.
78.Geiger B, Spatz JP, Bershadsky AD. Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol 2009;10:21–33.
79.Lv HW, Wang HP, Zhang ZJ, Yang W, Liu WB, Li YL et al. Biomaterial stiffness determines stem cell fate. Life Sci 2017;178:42–8.
80.Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M et al. Role of YAP/TAZ in mechanotransduction. Nature 2011;474:179–U212.
81.Chaudhuri O, Gu L, Klumpers D, Darnell M, Bencherif SA, Weaver JC et al. Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat Mater 2016;15: 326-+.
82.Cai L, Zhang L, Dong JY, Wang SF. Photocured biodegradable polymer substrates of varying stiffness and microgroove dimensions for promoting nerve cell guidance and differentiation. Langmuir 2012;28:12557–68.
83.Wang SF, Kempen DHR, de Ruiter GCW, Cai L, Spinner RJ, Windebank AJ et al. Molecularly engineered biodegradable polymer networks with a wide range of stiffness for bone and peripheral nerve regeneration. Adv Funct Mater 2015;25:2715–24.
84.Wu YB, Xiang Y, Fang JH, Li XK, Lin ZW, Dai GL et al. The influence of the stiffness of GelMA substrate on the outgrowth of PC12 cells. Biosci Rep 2019;39.
85.Gu Y, Ji Y, Zhao Y, Liu Y, Ding F, Gu X et al. The influence of substrate stiffness on the behavior and functions of Schwann cells in culture. Biomaterials 2012;33:6672–81.
86.Kayal C, Moeendarbary E, Shipley RJ, Phillips JB. Mechanical response of neural cells to physiologically relevant stiffness gradients. Adv Healthc Mater 2020;9.
87.Lavrentieva A, Fleischhammer T, Enders A, Pirmahboub H, Bahnemann J, Pepelanova I. Fabrication of stiffness gradients of GelMA hydrogels using a 3D printed micromixer. Macromol Biosci 2020;20:e2000107.
88.Vijayavenkataraman S, Zhang S, Thaharah S, Sriram G, Lu WF, Fuh JYH. Electrohydrodynamic jet 3D printed nerve guide conduits (NGCs) for peripheral nerve injury repair. Polymers 2018;10.
89.Vijayavenkataraman S, Thaharah S, Zhang S, Lu WF, Fuh JYH. 3D-printed PCL/rGO conductive scaffolds for peripheral nerve injury repair. Artif Organs 2019;43:515–23.
90.Vijayavenkataraman S, Thaharah S, Zhang S, Lu WF, Fuh JYH. Electrohydrodynamic jet 3D-printed PCL/PAA conductive scaffolds with tunable biodegradability as nerve guide conduits (NGCs) for peripheral nerve injury repair. Materials & Design 2019;162:171–84.
91.Qian Y, Yuan W-E, Cheng Y, Yang Y, Qu X, Fan C. Concentrically integrative bioassembly of a three-dimensional black phosphorus Nanoscaffold for restoring neurogenesis. Angiogenesis, and Immune Homeostasis Nano Letters 2019;19:8990–9001.
92.Qian Y, Zhao X, Han Q, Chen W, Li H, Yuan W. An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration. Nat Commun 2018;9.
93.Pampaloni NP, Lottner M, Giugliano M, Matruglio A, D'Amico F, Prato M et al. Single-layer graphene modulates neuronal communication and augments membrane ion currents. Nat Nanotechnol 2018;13: 755-+.
94.Park J, Jeon J, Kim B, Lee MS, Park S, Lim J et al. Electrically conductive hydrogel nerve guidance conduits for peripheral nerve regeneration. Adv Funct Mater 2020;30.
95.Qian Y, Cheng Y, Song J, Xu Y, Yuan W-E, Fan C et al. Mechano-informed biomimetic polymer scaffolds by incorporating self-powered zinc oxide Nanogenerators enhance motor recovery and neural function. Small 2020;16.
96.Cheng Y, Xu Y, Qian Y, Chen X, Ouyang Y, Yuan W-E. 3D structured self-powered PVDF/PCL scaffolds for peripheral nerve regeneration. Nano Energy 2020;69.
97.Fei J, Wen X, Lin X, Saijilafu WW, Ren O et al. Biocompatibility and neurotoxicity of magnesium alloys potentially used for neural repairs. Materials Science & Engineering C-Materials for Biological Applications 2017;78:1155–63.
98.Wang ZZ, Sakiyama-Elbert SE. Matrices, scaffolds & carriers for cell delivery in nerve regeneration. Exp Neurol 2019;319.
99.Cerqueira SR, Lee YS, Cornelison RC, Mertz MW, Wachs RA, Schmidt CE et al. Decellularized peripheral nerve supports Schwann cell transplants and axon growth following spinal cord injury. Biomaterials 2018;177:176–85.
100.Das S, Sharma M, Saharia D, Sarma KK, Sarma MG, Borthakur BB et al. In vivo studies of silk based gold nano-composite conduits for functional peripheral nerve regeneration. Biomaterials 2015;62:66–75.
101.Zhu S, Ge J, Wang Y, Qi F, Ma T, Wang M et al. A synthetic oxygen carrier-olfactory ensheathing cell composition system for the promotion of sciatic nerve regeneration. Biomaterials 2014;35:1450–61.
102.Yi S, Zhang Y, Gu X, Huang L, Zhang K, Qian T et al. Application of stem cells in peripheral nerve regeneration. Burns & Trauma 2020;8.
103.Zhang W, Zhang L, Liu J, Zhang L, Zhang J, Tang P. Repairing sciatic nerve injury with an EPO-loaded nerve conduit and sandwiched-in strategy of transplanting mesenchymal stem cells. Biomaterials 2017;142:90–100.
104.Du J, Zhen G, Chen H, Zhang S, Qing L, Yang X et al. Optimal electrical stimulation boosts stem cell therapy in nerve regeneration. Biomaterials 2018;181:347–59.
105.Hu N, Wu H, Xue C, Gong Y, Wu J, Xiao Z et al. Long-term outcome of the repair of 50 mm long median nerve defects in rhesus monkeys with marrow mesenchymal stem cells-containing, chitosan-based tissue engineered nerve grafts. Biomaterials 2013;34:100–11.
106.Marchesi C, Pluderi M, Colleoni F, Belicchi M, Meregalli M, Farini A et al. Skin-derived stem cells transplanted into resorbable guides provide functional nerve regeneration after sciatic nerve resection. Glia 2007;55:425–38.
107.Pan HC, Cheng FC, Chen CJ, Lai SZ, Lee CW, Yang DY et al. Post-injury regeneration in rat sciatic nerve facilitated by neurotrophic factors secreted by amniotic fluid mesenchymal stem cells. J Clin Neurosci 2007;14:1089–98.
108.Hu Z, An K, Wang J, Xu X, Chen Z, Hu J et al. Preparation and drug release behavior of tussah silk fibroin composite membrane. Fibers and Polymers 2020;21:252–61.
109.Chen R, Zhou L, Yang H, Zheng H, Zhou Y, Hu Z et al. Degradation behavior and immunological detection of silk fibroin exposure to enzymes. Anal Sci 2019;35:1243–9.
110.Kokai LE, Ghaznavi AM, Marra KG. Incorporation of double-walled microspheres into polymer nerve guides for the sustained delivery of glial cell line-derived neurotrophic factor. Biomaterials 2010;31:2313–22.
111.Nagappan PG, Chen H, Wang D-Y. Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury. Mil Med Res 2020;7.
112.Cui Y, Lu C, Meng D, Xiao Z, Hou X, Ding W et al. Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs. Biomaterials 2014;35:7819–27.
113.Tang S, Zhu J, Xu Y, Xiang AP, Jiang MH, Quan D. The effects of gradients of nerve growth factor immobilized PCLA scaffolds on neurite outgrowth in vitro and peripheral nerve regeneration in rats. Biomaterials 2013;34:7086–96.
114.Fadia NB, Bliley JM, DiBernardo GA, Crammond DJ, Schilling BK, Sivak WN et al. Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates. Sci Transl Med 2020;12.
115.Bota O, Fodor L. The influence of drugs on peripheral nerve regeneration. Drug Metab Rev 2019;51:266–92.
116.Chang HM, Liu CH, Hsu WM, Chen LY, Wang HP, Wu TH et al. Proliferative effects of melatonin on Schwann cells: implication for nerve regeneration following peripheral nerve injury. J Pineal Res 2014;56:322–32.
117.Qian Y, Han Q, Zhao X, Song J, Cheng Y, Fang Z et al. 3D melatonin nerve scaffold reduces oxidative stress and inflammation and increases autophagy in peripheral nerve regeneration. J Pineal Res 2018;65:e12516.
118.Xu X, Tao J, Wang S, Yang L, Zhang J, Zhang J et al. 3D printing of nerve conduits with nanoparticle-encapsulated RGFP966. Appl Mater Today 2019;16:247–56.
119.Pace LA, Plate JF, Smith TL, Van Dyke ME. The effect of human hair keratin hydrogel on early cellular response to sciatic nerve injury in a rat model. Biomaterials 2013;34:5907–14.
120.Masand SN, Chen J, Perron IJ, Hammerling BC, Loers G, Schachner M et al. The effect of glycomimetic functionalized collagen on peripheral nerve repair. Biomaterials 2012;33:8353–62.
121.Zhang JM, Chen YW, Huang YL, Wu WB, Deng XM, Liu HF et al. A 3D-printed self-adhesive bandage with drug release for peripheral nerve repair. Adv Sci 2020; n/a(n/a):2002601.
122.Yan Z, Qian Y. Rectify the injury-induced microenvironment imbalance in peripheral nerve repair. Adv Mater Let 2020;11:20101562.
123.Joung D, Lavoie NS, Guo S-Z, Park SH, Parr AM, McAlpine MC. 3D printed neural regeneration devices. Adv Funct Mater 2020;30.
0
Views
0
下载量
0
CSCD
- L-PDFDownload
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
