Low-protein diet accelerates wound healing in mice post-acute injury

Jonathan J Hew; Roxanne J Parungao; Craig P Mooney; Julian K Smyth; Sarah Kim; Kevin H-Y Tsai; Huaikai Shi; Cassandra Chong; Renee C F Chan; Beba Attia; Caroline Nicholls; Zhe Li; Samantha M Solon-Biet; David G Le Couteur; Stephen J Simpson; Marc G Jeschke; Peter K Maitz; Yiwei Wang

doi:10.1093/burnst/tkab010

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Low-protein diet accelerates wound healing in mice post-acute injury

更新时间：2022-06-14

- Low-protein diet accelerates wound healing in mice post-acute injury
- Burns & Trauma Vol. 9, Issue 1, (2021)
- 作者机构：
  
  1. Burns Research and Reconstructive Surgery
  2. Bone Biology Group
  3. Adrenal Steroids Laboratory
  4. Electron Microscopy Unit
  5. Burns Unit
  6. Ageing and Alzheimer Institute and ANZAC Research Institute
  7. Charles Perkins Centre and School of Life and Environmental Sciences
  8. Sunnybrook Research Institute
  9. School of Pharmacy
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkab010
  CLC：
- Published：2021，
  
  Published Online：9 August 2021，
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Jonathan J Hew, Roxanne J Parungao, Craig P Mooney, Julian K Smyth, Sarah Kim, Kevin H-Y Tsai, Huaikai Shi, Cassandra Chong, Renee C F Chan, Beba Attia, Caroline Nicholls, Zhe Li, Samantha M Solon-Biet, David G Le Couteur, Stephen J Simpson, Marc G Jeschke, Peter K Maitz, Yiwei Wang, Low-protein diet accelerates wound healing in mice post-acute injury, Burns & Trauma, Volume 9, 2021, tkab010, https://doi.org/10.1093/burnst/tkab010
DOI：

Jonathan J Hew, Roxanne J Parungao, Craig P Mooney, Julian K Smyth, Sarah Kim, Kevin H-Y Tsai, Huaikai Shi, Cassandra Chong, Renee C F Chan, Beba Attia, Caroline Nicholls, Zhe Li, Samantha M Solon-Biet, David G Le Couteur, Stephen J Simpson, Marc G Jeschke, Peter K Maitz, Yiwei Wang, Low-protein diet accelerates wound healing in mice post-acute injury, Burns & Trauma, Volume 9, 2021, tkab010, https://doi.org/10.1093/burnst/tkab010 DOI：

摘要

Abstract

BackgroundWound healing processes are influenced by macronutrient intake (protein

carbohydrate and fat). The most favourable diet for cutaneous wound healing is not known

although high-protein diets are currently favoured clinically. This experimental study investigates the optimal macronutrient balance for cutaneous wound healing using a mouse model and the Geometric Framework

a nutrient modelling method

capable of analyzing the individual and interactive effects of a wide spectrum of macronutrient intake.MethodsTwo adjacent and identical full-thickness skin excisions (1 cm2) were surgically created on the dorsal area of male C57BL/6 mice. Mice were then allocated to one of 12 high-energy diets that varied in protein

carbohydrate and fat content. In select diets

wound healing processes

cytokine expression

energy expenditure

body composition

muscle and fat reserves were assessed.ResultsUsing the Geometric Framework

we show that a low-protein intake

coupled with a balanced intake of carbohydrate and fat is optimal for wound healing. Mice fed a low-protein diet progressed quickly through wound healing stages with favourable wound inflammatory cytokine expression and significantly accelerated collagen production. These local processes were associated with an increased early systemic inflammatory response and a higher overall energy expenditure

related to metabolic changes occurring in key macronutrient reserves in lean body mass and fat depots.ConclusionsThe results suggest that a low-protein diet may have a greater potential to accelerate wound healing than the current clinically used high-protein diets.

关键词

Keywords

Wound healingMacronutrientsCutaneousGeometric FrameworkMouse modelLow-protein dietNutrition

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