The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing
- Burns & Trauma Vol. 9, Issue 1, (2021)
- 作者机构：
1. State Key Laboratory of Trauma
2. Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics
3. NHC Key Laboratory of Hormones and Development
4. Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University
5. Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Medical University
6. Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University
7. The Biomedical Translational Research Institute
8. Jinan University
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkab009
CLC：Published：2021，
Published Online：23 June 2021，
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Cheng Chen, Ziyu Meng, He Ren, Na Zhao, Ruoyu Shang, Weifeng He, Jianlei Hao, The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing, Burns & Trauma, Volume 9, 2021, tkab009, https://doi.org/10.1093/burnst/tkab009
Cheng Chen, Ziyu Meng, He Ren, Na Zhao, Ruoyu Shang, Weifeng He, Jianlei Hao, The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing, Burns & Trauma, Volume 9, 2021, tkab009, https://doi.org/10.1093/burnst/tkab009 DOI：
摘要
Abstract
The epidermis is the outermost layer of skin and the first barrier against invasion. Dendritic epidermal T cells (DETCs) are a subset of γδ T cells and an important component of the epidermal immune microenvironment. DETCs are involved in skin wound healing
malignancy and autoimmune diseases. DETCs secrete insulin-like growth factor-1 and keratinocyte growth factor for skin homeostasis and re-epithelization and release inflammatory factors to adjust the inflammatory microenvironment of wound healing. Therefore
an understanding of their development
activation and correlative signalling pathways is indispensable for the regulation of DETCs to accelerate wound healing. Our review focuses on the above-mentioned molecular mechanisms to provide a general research framework to regulate and control the function of DETCs.
关键词
Keywords
Dendritic epidermal T cellsWound healingγδ T cellsCytokinesCytokine receptorsSignalling pathwaysskin
references
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