Mesenchymal stem cell-based therapy for burn wound healing
- Burns & Trauma Vol. 9, Issue 1, (2021)
- 作者机构：
Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkab002
CLC：Published：2021，
Published Online：1 May 2021，
扫 描 看 全 文
Mingyao Wang, Xinxuan Xu, Xiongxin Lei, Jie Tan, Huiqi Xie, Mesenchymal stem cell-based therapy for burn wound healing, Burns & Trauma, Volume 9, 2021, tkab002, https://doi.org/10.1093/burnst/tkab002
摘要
Abstract
Burns
with their high incidence and mortality rates
have a devastating effect on patients. There are still huge challenges in the management of burns. Mesenchymal stem cells (MSCs)
which have multidirectional differentiation potential
have aroused interest in exploring the capacity for treating different intractable diseases due to their strong proliferation
tissue repair
immune tolerance and paracrine abilities
among other features. Currently
several animal studies have shown that MSCs play various roles and have beneficial effects in promoting wound healing
inhibiting burn inflammation and preventing the formation of pathological scars during burn healing process. The substances MSCs secrete can act on peripheral cells and promote burn repair. According to preclinical research
MSC-based treatments can effectively improve burn wound healing and reduce pain. However
due to the small number of patients and the lack of controls
treatment plans and evaluation criteria vary widely
thus limiting the value of these clinical studies. Therefore
to better evaluate the safety and effectiveness of MSC-based burn treatments
standardization of the application scheme and evaluation criteria of MSC therapy in burn treatment is required in the future. In addition
the combination of MSC pretreatment and dressing materials are also conducive to improving the therapeutic effect of MSCs on burns. In this article
we review current animal research and clinical trials based on the use of stem cell therapy for treating burns and discuss the main challenges and coping strategies facing future clinical applications.
关键词
Keywords
BurnWound healingStem cell-based therapyClinical trialRegenerative medicineProliferationTissue repairInflammation
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