A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns
- Burns & Trauma Vol. 9, Issue 1, (2021)
- 作者机构：
1. Queensland University of Technology (QUT), Centre for Children’s Burn and Trauma Research, Centre for Children’s Health Research
2. Queensland University of Technology (QUT)
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkaa049
CLC：Published：2021，
Published Online：9 February 2021，
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Morgan Carlton, Joanne Voisey, Tony J Parker, Chamindie Punyadeera, Leila Cuttle, A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns, Burns & Trauma, Volume 9, 2021, tkaa049, https://doi.org/10.1093/burnst/tkaa049
摘要
Abstract
Biological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric burns. The objective of this review is to summarize the evidence supporting the use of biomarkers in children with burns. An extensive review of the literature was performed using PubMed. A total of 59 biomarkers were identified relating to burn presence
specifically relating to processes involved in inflammation
wound healing
growth and metabolism. In addition
biomarkers involved in the stress response cascade following a burn trauma were also identified. Although many biomarkers have been identified that are potentially associated with burn-related physical and psychological trauma
an understanding of burn biology is still lacking in children. We propose that future research in the field of children’s burns should be conducted using broad screening methods for identifying potential biomarkers
examine the biological interactions of different biomarkers
utilize child-appropriate biological fluids such as urine or saliva
and include a range of different severity burns. Through further research
the biological response to burn injury may be fully realized and clinically relevant diagnostic tests and treatment therapies utilizing these biomarkers could be developed
for the improvement of healing outcomes in paediatric burn patients.
关键词
Keywords
Paediatric burnsBiomarkerInflammatoryHypothalamic-pituitary-adrenal axisPhysical traumaPsychological trauma
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