The pathogenesis and diagnosis of sepsis post burn injury

Pengju Zhang; Bingwen Zou; Yih-Cherng Liou; Canhua Huang

doi:10.1093/burnst/tkaa047

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The pathogenesis and diagnosis of sepsis post burn injury

更新时间：2022-06-14

- The pathogenesis and diagnosis of sepsis post burn injury
- Burns & Trauma Vol. 9, Issue 1, (2021)
- 作者机构：
  
  1. State Key Laboratory of Biotherapy and Cancer Center
  2. and West China School of Basic Medical Sciences & Forensic Medicine
  3. Department of Thoracic Oncology and Department of Radiation Oncology
  4. Sichuan University
  5. Department of Biological Sciences
  6. National University of Singapore
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkaa047
  CLC：
- Published：2021，
  
  Published Online：4 February 2021，
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Pengju Zhang, Bingwen Zou, Yih-Cherng Liou, Canhua Huang, The pathogenesis and diagnosis of sepsis post burn injury, Burns & Trauma, Volume 9, 2021, tkaa047, https://doi.org/10.1093/burnst/tkaa047
DOI：

Pengju Zhang, Bingwen Zou, Yih-Cherng Liou, Canhua Huang, The pathogenesis and diagnosis of sepsis post burn injury, Burns & Trauma, Volume 9, 2021, tkaa047, https://doi.org/10.1093/burnst/tkaa047 DOI：

摘要

Abstract

Burn is an under-appreciated trauma that is associated with unacceptably high morbidity and mortality. Although the survival rate after devastating burn injuries has continued to increase in previous decades due to medical advances in burn wound care

nutritional and fluid resuscitation and improved infection control practices

there are still large numbers of patients at a high risk of death. One of the most common complications of burn is sepsis

which is defined as “severe organ dysfunction attributed to host's disordered response to infection” and is the primary cause of death in burn patients. Indeed

burn injuries are accompanied by a series of events that lead to sepsis and multiple organ dysfunction syndrome

such as a hypovolaemic state

immune and inflammatory responses and metabolic changes. Therefore

clear diagnostic criteria and predictive biomarkers are especially important in the prevention and treatment of sepsis and septic shock. In this review

we focus on the pathogenesis of burn wound infection and the post-burn events leading to sepsis. Moreover

the clinical and promising biomarkers of burn sepsis will also be summarized.

关键词

Keywords

BurnInfectionSepsisSeptic shockMultiple organ dysfunction syndromeImmune dysregulationHypermetabolismTraumaBiomakerInflammation

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