Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor β suppression in hematopoietic stem cells

Weiguo Xie; Xueqing Zhou; Weigang Hu; Zhigang Chu; Qiongfang Ruan; Haimou Zhang; Min Li; Hongyu Zhang; Xiaodong Huang; Paul Yao

doi:10.1093/burnst/tkaa045

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Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor β suppression in hematopoietic stem cells

更新时间：2022-06-14

- Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor β suppression in hematopoietic stem cells
- Burns & Trauma Vol. 9, Issue 1, (2021)
- 作者机构：
  
  1. Institute of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital)
  2. State Key Lab of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University
  3. Department of Hematology, Peking University Shenzhen Hospital
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkaa045
  CLC：
- Published：2021，
  
  Published Online：22 February 2021，
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Weiguo Xie, Xueqing Zhou, Weigang Hu, Zhigang Chu, Qiongfang Ruan, Haimou Zhang, Min Li, Hongyu Zhang, Xiaodong Huang, Paul Yao, Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor β suppression in hematopoietic stem cells, Burns & Trauma, Volume 9, 2021, tkaa045, https://doi.org/10.1093/burnst/tkaa045
DOI：

Weiguo Xie, Xueqing Zhou, Weigang Hu, Zhigang Chu, Qiongfang Ruan, Haimou Zhang, Min Li, Hongyu Zhang, Xiaodong Huang, Paul Yao, Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor β suppression in hematopoietic stem cells, Burns & Trauma, Volume 9, 2021, tkaa045, https://doi.org/10.1093/burnst/tkaa045 DOI：

摘要

Abstract

BackgroundDelayed wound healing is one of the major complications of diabetes mellitus and is characterized by prolonged inflammation

delayed re-epithelialization and consistent oxidative stress

although the detailed mechanism remains unknown. In this study

we aimed to investigate the potential role and effect of pterostilbene (PTE) and hematopoietic stem cells (HSCs) on diabetic wound healing.MethodsDiabetic rats were used to measure the epigenetic changes in both HSCs and peripheral blood mononuclear cells (PBMCs). A cutaneous burn injury was induced in the rats and PTE-treated diabetic HSCs were transplanted for evaluation of wound healing. In addition

several biomedical parameters

including gene expression

oxidative stress

mitochondrial function and inflammation in macrophages

were also measured.ResultsOur data showed that PTE had a much stronger effect than resveratrol on accelerating diabetic wound healing

likely because PTE can ameliorate diabetes-induced epigenetic changes to estrogen receptor β promoter in HSCs

while resveratrol cannot. Further investigation showed that bone marrow transplantation of PTE-treated diabetic HSCs restores diabetes-induced suppression of estrogen receptor β and its target genes

including nuclear respiratory factor-1 and superoxide dismutase 2

and protects against diabetes-induced oxidative stress

mitochondrial dysfunction and elevated pro-inflammatory cytokines in both PBMCs and macrophages

subsequently accelerating cutaneous wound healing.ConclusionsHSC may play an important role in wound healing through transferring epigenetic modifications to subsequent PBMCs and macrophages by differentiation

while PTE accelerates diabetic wound healing by modulating diabetes-induced epigenetic changes in HSCs. Thus

PTE may be a novel therapeutic strategy for diabetic wound healing.

关键词

Keywords

Hematopoietic stem cellsInflammationOxidative stressPterostilbeneWound healing

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