Co-Cr-Mo-Cu alloys for clinical implants with osteogenic effect by increasing bone induction, formation and development in a rabbit model

Jingzhu Duan; Yang Yang; Erlin Zhang; Huan Wang

doi:10.1093/burnst/tkaa036

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Co-Cr-Mo-Cu alloys for clinical implants with osteogenic effect by increasing bone induction, formation and development in a rabbit model

更新时间：2022-06-09

- Co-Cr-Mo-Cu alloys for clinical implants with osteogenic effect by increasing bone induction, formation and development in a rabbit model
- Burns & Trauma Vol. 8, Issue 1, (2020)
- 作者机构：
  
  1. Department of Orthopaedic, Shengjing Hospital of China Medical University
  2. Department of Ophthalmology, Shengjing Hospital of China Medical University
  3. Key Laboratory for Anisotropy and Texture of Materials, Education Ministry of China, School of Materials Science and Engineering, Northeastern University
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkaa036
  CLC：
- Published：2020，
  
  Published Online：21 December 2020，
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Jingzhu Duan, Yang Yang, Erlin Zhang, Huan Wang, Co-Cr-Mo-Cu alloys for clinical implants with osteogenic effect by increasing bone induction, formation and development in a rabbit model, Burns & Trauma, Volume 8, 2020, tkaa036, https://doi.org/10.1093/burnst/tkaa036
DOI：

Jingzhu Duan, Yang Yang, Erlin Zhang, Huan Wang, Co-Cr-Mo-Cu alloys for clinical implants with osteogenic effect by increasing bone induction, formation and development in a rabbit model, Burns & Trauma, Volume 8, 2020, tkaa036, https://doi.org/10.1093/burnst/tkaa036 DOI：

摘要

Abstract

BackgroundCo-Cr-Mo alloy has been widely used in clinical implants because of its excellent mechanical and anti-corrosion properties

but there is an urgent need to address its disadvantages

such as implant-related infections and implant loosening. We synthesized Co-Cr-Mo-Cu (Co-Cu) alloys with different Cu contents to modify implant performance to be suitable as a bone-compatible implant material.MethodsMicrostructure

phase content and mechanical properties of the Co-Cr-Mo alloy were characterized. Histological and immunohistochemical analyses were performed after implantation in rabbits. The experimental alloy was implanted on the lateral side of the lower tibial condyle and the tibial nodule.ResultsPhase content and mechanical properties revealed that the crystallographic structure and wear resistance were changed. Experimental implantation results demonstrated that osteogenic capability was markedly enhanced

ascribed to the excellent antibacterial and osseointegration capacities of Cu phases

and with the release of Cu ions. In particular

Co-Cu alloy containing 2 wt% Cu exhibited the best osteogenic performance among all samples.ConclusionsThe results indicated that osteogenic performance of the Co-Cr-Mo alloy could be enhanced by adding Cu. In particular

the Co-2Cu alloy exhibited the best properties according to both immunohistochemical and histological analyses. Our study not only provides deep insight into the osteogenic effect of Cu but presents a new Co-Cu alloy for clinical implants.

关键词

Keywords

Co-Cr-Mu-Cu alloyCu ionOsteogenic capabilityImplantable operationClinical application

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