Microbiome in the setting of burn patients: implications for infections and clinical outcomes

Silvia Corcione; Tommaso Lupia; Francesco G De Rosa; Host and Microbiota Interaction Study Group (ESGHAMI) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)

doi:10.1093/burnst/tkaa033

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Microbiome in the setting of burn patients: implications for infections and clinical outcomes

更新时间：2022-06-09

- Microbiome in the setting of burn patients: implications for infections and clinical outcomes
- Burns & Trauma Vol. 8, Issue 1, (2020)
- 作者机构：
  
  1. Department of Medical Sciences
  2. University of Turin
  3. Tufts University School of Medicine
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkaa033
  CLC：
- Published：2020，
  
  Published Online：14 August 2020，
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Silvia Corcione, Tommaso Lupia, Francesco G De Rosa, Host and Microbiota Interaction Study Group (ESGHAMI) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Microbiome in the setting of burn patients: implications for infections and clinical outcomes, Burns & Trauma, Volume 8, 2020, tkaa033, https://doi.org/10.1093/burnst/tkaa033
DOI：

Silvia Corcione, Tommaso Lupia, Francesco G De Rosa, Host and Microbiota Interaction Study Group (ESGHAMI) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Microbiome in the setting of burn patients: implications for infections and clinical outcomes, Burns & Trauma, Volume 8, 2020, tkaa033, https://doi.org/10.1093/burnst/tkaa033 DOI：

摘要

Abstract

Burn damage can lead to a state of immune dysregulation that facilitates the development of infections in patients. The most deleterious impact of this dysfunction is the loss of the skin’s natural protective barrier. Furthermore

the risk of infection is exacerbated by protracted hospitalization

urinary catheters

endotracheal intubation

inhalation injury

arterial lines and central venous access

among other mainstays of burn care. Currently

infections comprise the leading cause of mortality after major burn injuries

which highlights the improvements observed over the last 50 years in the care provided to burn victims. The need to implement the empirical selection of antibiotic therapy to treat multidrug-resistant bacteria may concomitantly lead to an overall pervasiveness of difficult-to-treat pathogens in burn centres

as well as the propagation of antimicrobial resistance and the ultimate dysregulation of a healthy microbiome. While preliminary studies are examining the variability and evolution of human and mice microbiota

both during the early and late phase burn injury

one must consider that abnormal microbiome conditions could influence the systemic inflammatory response. A better understanding of the changes in the post-burn microbiome might be useful to interpret the provenance and subsequent development of infections

as well as to come up with inferences on the prognosis of burn patients. This review aims to summarise the current findings describing the microbiological changes in different organs and systems of burn patients and how these alterations affect the risks of infections

complications

and

ultimately

healing.

关键词

Keywords

BurnMicrobiomeSkin microbiomeGut microbiomeLung microbiomeMultidrug-resistant organisms

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