Vascularization is the next challenge for skin tissue engineering as a solution for burn management
- Burns & Trauma Vol. 8, Issue 1, (2020)
- 作者机构：
1. Department of Hand Surgery and Plastic Surgery and Burns
2. The Department of Biomedical and Clinical Sciences
3. Faculty of Biotechnology
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkaa022
CLC：Published：2020，
Published Online：3 August 2020，
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Hady Shahin, Moustafa Elmasry, Ingrid Steinvall, Folke Söberg, Ahmed El-Serafi, Vascularization is the next challenge for skin tissue engineering as a solution for burn management, Burns & Trauma, Volume 8, 2020, tkaa022, https://doi.org/10.1093/burnst/tkaa022
摘要
Abstract
Skin regeneration represents a promising line of management for patients with skin loss
including burn victims. The current approach of spraying single cells over the defective areas results in variable success rates in different centers. The modern approach is to synthesize a multilayer skin construct that is based on autologous stem cells. One of the main complications with different types of transplants is sloughing due to the absence of proper vascularization. Ensuring proper vascularization will be crucial for the integration of skin constructs with the surrounding tissues. Combination of the right cells with scaffolds of proper physico-chemical properties
vascularization can be markedly enhanced. The material effect
pore size and adsorption of certain proteins
as well as the application of appropriate growth factors
such as vascular endothelial growth factors
can have an additive effect. A selection of the most effective protocols is discussed in this review.
关键词
Keywords
BurnskinRegenerationTissue engineeringVascularization
references
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