The role of macrophages in the formation of hypertrophic scars and keloids
- Burns & Trauma Vol. 8, Issue 1, (2020)
- 作者机构：
Department of Plastic and Reconstructive Surgery
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkaa006
CLC：Published：2020，
Published Online：11 March 2020，
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Xiangwen Xu, Shuchen Gu, Xin Huang, Jieyi Ren, Yihui Gu, Chengjiang Wei, Xiang Lian, Haizhou Li, Yashan Gao, Rui Jin, Bin Gu, Tao Zan, Zhichao Wang, The role of macrophages in the formation of hypertrophic scars and keloids, Burns & Trauma, Volume 8, 2020, tkaa006, https://doi.org/10.1093/burnst/tkaa006
Xiangwen Xu, Shuchen Gu, Xin Huang, Jieyi Ren, Yihui Gu, Chengjiang Wei, Xiang Lian, Haizhou Li, Yashan Gao, Rui Jin, Bin Gu, Tao Zan, Zhichao Wang, The role of macrophages in the formation of hypertrophic scars and keloids, Burns & Trauma, Volume 8, 2020, tkaa006, https://doi.org/10.1093/burnst/tkaa006 DOI：
摘要
Abstract
Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation. However
few reviews have highlighted the significance of macrophages during the formation of abnormal scars. The purpose of this review was to outline the polarization of macrophages from early to late stage of pathological scar formation
focusing on spatiotemporal diversity of M1 and M2 macrophages. In this review
the role of macrophages in the formation of hypertrophic scars and keloids is summarized in detail. First
an increased number of M2 cells observed before injuries are significantly associated with susceptibility to abnormal scar pathogenesis. Second
decreased expression of M1 at the early stage and delayed expression of M2 at the late stage results in pathological scar formation. Third
M2 cells are highly expressed at both the margin and the superficial region
which is consistent with the invasive property of keloids. Finally
this review helps to characterize strategies for the prediction and prevention of pathological scar formation.
关键词
Keywords
Hypertrophic scarKeloidMacrophagesPredispositionWound healing
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