Application of stem cells in peripheral nerve regeneration
- Burns & Trauma Vol. 8, Issue 1, (2020)
- 作者机构：
1. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education
2. Nuclear Medicine Department
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkaa002
CLC：Published：2020，
Published Online：27 February 2020，
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Sheng Yi, Yu Zhang, Xiaokun Gu, Li Huang, Kairong Zhang, Tianmei Qian, Xiaosong Gu, Application of stem cells in peripheral nerve regeneration, Burns & Trauma, Volume 8, 2020, tkaa002, https://doi.org/10.1093/burnst/tkaa002
摘要
Abstract
Traumatic peripheral nerve injury is a worldwide clinical issue with high morbidity. The severity of peripheral nerve injury can be classified as neurapraxia
axonotmesis or neurotmesis
according to Seddon’s classification
or five different degrees according to Sunderland’s classification. Patients with neurotmesis suffer from a complete transection of peripheral nerve stumps and are often in need of surgical repair of nerve defects. The applications of autologous nerve grafts as the golden standard for peripheral nerve transplantation meet some difficulties
including donor nerve sacrifice and nerve mismatch. Attempts have been made to construct tissue-engineered nerve grafts as supplements or even substitutes for autologous nerve grafts to bridge peripheral nerve defects. The incorporation of stem cells as seed cells into the biomaterial-based scaffolds increases the effectiveness of tissue-engineered nerve grafts and largely boosts the regenerative process. Numerous stem cells
including embryonic stem cells
neural stem cells
bone marrow mesenchymal stem cells
adipose stem cells
skin-derived precursor stem cells and induced pluripotent stem cells
have been used in neural tissue engineering. In the current review
recent trials of stem cell-based tissue-engineered nerve grafts have been summarized; potential concerns and perspectives of stem cell therapeutics have also been contemplated.
关键词
Keywords
Peripheral nerve injuryTissue-engineered nerve graftsSeed cellsStem cellsPeripheral nerve regeneration
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