Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis

Shuyu Li; Zichen Xu; Yi Wang; Lizhao Chen; Xiangxiu Wang; Yanghao Zhou; Daoxi Lei; Guangchao Zang; Guixue Wang

doi:10.1016/j.gendis.2023.06.016

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Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis

Review article | 更新时间：2024-02-04

- Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis
- Genes & Diseases Vol. 11, Issue 3, (2024)
- 作者机构：
  
  1. Key Laboratory of Biorheological Science and Technology of Ministry of Education, National and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University,Chongqing,China,400030
  2. Department of Neurosurgery, Daping Hospital, Army Medical Center of PLA, Army Medical University,Chongqing,China,400042
  3. College of Basic Medical Sciences, Chongqing Medical University,Chongqing,China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.06.016
  CLC：
- Published：2024，
  
  Published Online：1 May 2024，
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Shuyu Li, Zichen Xu, Yi Wang, et al. Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis. [J]. Genes & Diseases 11(3).(2024)
DOI：

Shuyu Li, Zichen Xu, Yi Wang, et al. Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis. [J]. Genes & Diseases 11(3).(2024) DOI： 10.1016/j.gendis.2023.06.016.

摘要

Abstract

herosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide. Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells

and it plays an important role in gene regulation of pro-inflammatory

pro-thrombotic

pro-oxidative stress

and cell permeability. Many important endothelial cell mechanosensitive genes have been discovered

including

KLK10

CCN

gene family

NRP2

YAP

TAZ

HIF-1α

NF-κB

FOS

JUN

TFEB

KLF2/KLF4

NRF2

and

ID1

. Some of them have been intensively studied

whereas the relevant regulatory mechanism of other genes remains unclear. Focusing on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular disease. Thus

this article reviews the mechanosensitive genes affecting vascular endothelial cells

including classical pathways and some newly screened genes

and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights for anti-atherosclerosis.

关键词

Keywords

AtherosclerosisBlood flowEndothelial cellMechanosensitive geneTherapeutic target

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