Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions

Yancheng Lai; Xiaole Lu; Yankai Liao; Pei Ouyang; Hai Wang; Xian Zhang; Guanglong Huang; Songtao Qi; Yaomin Li

doi:10.1016/j.gendis.2023.05.025

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Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions

Review article | 更新时间：2024-02-04

- Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions
- Genes & Diseases Vol. 11, Issue 2, (2024)
- 作者机构：
  
  1. Department of Neurosurgery, Institute of Brain Disease, Nanfang Hospital, Southern Medical University,Guangdong,Guangzhou,China,510515
  2. Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University,Guangdong,Guangzhou,China,510515
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.05.025
  CLC：
- Published：2024，
  
  Published Online：1 March 2024，
扫描看全文
Yancheng Lai, Xiaole Lu, Yankai Liao, et al. Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions. [J]. Genes & Diseases 11(2).(2024)
DOI：

Yancheng Lai, Xiaole Lu, Yankai Liao, et al. Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions. [J]. Genes & Diseases 11(2).(2024) DOI： 10.1016/j.gendis.2023.05.025.

摘要

Abstract

Glioblastoma (GBM) is the most common intrinsic and aggressive primary brain tumor in adults

with a median survival of approximately 15 months. GBM heterogeneity is considered responsible for the treatment resistance and unfavorable prognosis. Proneural-mesenchymal transition (PMT) represents GBM malignant progression and recurrence

which might be a breakthrough to understand GBM heterogeneity and overcome treatment resistance. PMT is a complicated process influenced by crosstalk between GBM and tumor microenvironment

depending on intricate ligand-receptor interactions. In this review

we summarize the autocrine and paracrine pathways in the GBM microenvironment and related ligand-receptor interactions inducing PMT. We also discuss the current therapies targeting the PMT-related autocrine and paracrine pathways. Together

this review offers a comprehensive understanding of the failure of GBM-targeted therapy and ideas for future tendencies of GBM treatment.

关键词

Keywords

AutocrineGlioblastomaLigand-receptor interactionMicroenvironmentParacrineProneural-mesenchymal transition

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