FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases

Wei Shen; Modan Yang; Hao Chen; Chiyu He; Huigang Li; Xinyu Yang; Jianyong Zhuo; Zuyuan Lin; Zhihang Hu; Di Lu; Xiao Xu

doi:10.1016/j.gendis.2023.05.019

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FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases

Review article | 更新时间：2024-02-04

- FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases
- Genes & Diseases Vol. 11, Issue 3, (2024)
- 作者机构：
  
  1. National Center for Healthcare Quality Management in Liver Transplant,Zhejiang,Hangzhou,China,310003
  2. Zhejiang University School of Medicine,Zhejiang,Hangzhou,China,310058
  3. Institute of Organ Transplantation, Zhejiang University,Zhejiang,Hangzhou,China,310003
  4. The Institute for Organ Repair and Regenerative Medicine of Hangzhou,Zhejiang,Hangzhou,China,310006
  5. Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine,Zhejiang,Hangzhou,China,310006
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.05.019
  CLC：
- Published：2024，
  
  Published Online：1 May 2024，
扫描看全文
Wei Shen, Modan Yang, Hao Chen, et al. FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases. [J]. Genes & Diseases 11(3).(2024)
DOI：

Wei Shen, Modan Yang, Hao Chen, et al. FGF21-mediated autophagy: Remodeling the homeostasis in response to stress in liver diseases. [J]. Genes & Diseases 11(3).(2024) DOI： 10.1016/j.gendis.2023.05.019.

摘要

Abstract

Liver diseases are worldwide problems closely associated with various stresses

such as endoplasmic reticulum stress. The exact interplay between stress and liver diseases remains unclear. Autophagy plays an essential role in maintaining homeostasis

and recent studies indicate tight crosstalk between stress and autophagy in liver diseases. Once the balance between damage and autophagy is broken

autophagy can no longer resist injury or maintain homeostasis. In recent years

FGF21 (fibroblast growth factor 21)-induced autophagy has attracted much attention. FGF21 is regarded as a stress hormone and can be up-regulated by an abundance of signaling pathways in response to stress. Also

increased FGF21 activates autophagy by a complicated signaling network in which mTOR plays a pivotal role. This review summarizes the mechanism of FGF21-mediated autophagy and its derived application in the defense of stress in liver diseases and offers a glimpse into its promising prospect in future clinical practice.

关键词

Keywords

AutophagyFibroblast growth factor 21Liver diseasesStress

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Related Institution

The Key Laboratory of Anti-inflammatory and Immune Medicines, Anhui Medical University, Ministry of Education

Institute for Liver Diseases of Anhui Medical University, ILD-AMU, Anhui Medical University

Department of Oncology, The First Affiliated Hospital of Anhui Medical University

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University

Department of Nephropathy, The First Affiliated Hospital of Anhui Medical University

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