The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

Michael Yu; Kevin Qin; Jiaming Fan; Guozhi Zhao; Piao Zhao; Wei Zeng; Connie Chen; Annie Wang; Yonghui Wang; Jiamin Zhong; Yi Zhu; William Wagstaff; Rex C. Haydon; Hue H. Luu; Sherwin Ho; Michael J. Lee; Jason Strelzow; Russell R. Reid; Tong-Chuan He

doi:10.1016/j.gendis.2023.04.042

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The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

Review article | 更新时间：2024-02-04

- The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities
- Genes & Diseases Vol. 11, Issue 3, (2024)
- 作者机构：
  
  1. Department of Urology, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016
  2. School of Medicine, Rosalind Franklin University of Medicine and Science, North Chicago,IL,USA,60064
  3. Department of Clinical Laboratory Medicine, Shanghai Jiaotong University School of Medicine,Shanghai,China,200000
  4. Laboratory of Craniofacial Suture Biology and Development, Department of Surgery Section of Plastic Surgery, The University of Chicago Medical Center,IL,Chicago,USA,60637
  5. Department of Neurology, The First Dongguan Affiliated Hospital, Guangdong Medical University,Guangdong,Dongguan,China,523475
  6. Department of Orthopaedic Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China,100730
  7. Molecular Oncology Laboratory, Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center,IL,Chicago,USA,60637
  8. Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016
  9. Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, The School of Laboratory Medicine, Chongqing Medical University,Chongqing,China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.04.042
  CLC：
- Published：2024，
  
  Published Online：1 May 2024，
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Michael Yu, Kevin Qin, Jiaming Fan, et al. The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities. [J]. Genes & Diseases 11(3).(2024)
DOI：

Michael Yu, Kevin Qin, Jiaming Fan, et al. The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities. [J]. Genes & Diseases 11(3).(2024) DOI： 10.1016/j.gendis.2023.04.042.

摘要

Abstract

The evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted

lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non-canonical (β-catenin independent) Wnt signaling pathways. Cellular behaviors such as proliferation

differentiation

maturation

and proper body-axis specification are carried out by the canonical pathway

which is the best characterized of the known Wnt signaling paths. Wnt signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various tissues. This includes but is not limited to embryonic

hematopoietic

mesenchymal

gut

neural

and epidermal stem cells. Wnt signaling has also been implicated in tumor cells that exhibit stem cell-like properties. Wnt signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone disorders. Not surprisingly

aberrant Wnt signaling is also associated with a wide variety of diseases

including cancer. Mutations of Wnt pathway members in cancer can lead to unchecked cell proliferation

epithelial–mesenchymal transition

and metastasis. Altogether

advances in the understanding of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt pathway. Beginning with a brief overview of the mechanisms of canonical and non-canonical Wnt

this review aims to summarize the current knowledge of Wnt signaling in stem cells

aberrations to the Wnt pathway associated with diseases

and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词

Keywords

β-cateninCancerCanonical WntDiseaseNon-canonical WntStem cellsTargeted therapyWnt signaling

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Related Institution

Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center

Departments of Orthopaedic Surgery and Urology, The First Affiliated Hospital of Chongqing Medical University

Department of Interventional Neurology, The First Dongguan Affiliated Hospital, Guangdong Medical University

Laboratory of Craniofacial Biology and Development, Department of Surgery Section of Plastic Surgery, The University of Chicago Medical Center

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