Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies

Salma Nassor Juma; Junguang Liao; Yuping Huang; Rexhina Vlashi; Qingwan Wang; Bocong Wu; Dan Wang; Mengrui Wu; Guiqian Chen

doi:10.1016/j.gendis.2023.04.021

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Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies

Review article | 更新时间：2024-02-04

- Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies
- Genes & Diseases Vol. 11, Issue 3, (2024)
- 作者机构：
  
  1. College of Life Science and Medicine, Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Zhejiang Sci-Tech University,Zhejiang,Hangzhou,China,310018
  2. Department of Cell and Developmental Biology, College of Life Sciences, Zhejiang University,Zhejiang,Hangzhou,China,310058
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.04.021
  CLC：
- Published：2024，
  
  Published Online：1 May 2024，
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Salma Nassor Juma, Junguang Liao, Yuping Huang, et al. Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies. [J]. Genes & Diseases 11(3).(2024)
DOI：

Salma Nassor Juma, Junguang Liao, Yuping Huang, et al. Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies. [J]. Genes & Diseases 11(3).(2024) DOI： 10.1016/j.gendis.2023.04.021.

摘要

Abstract

Osteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar yet also different manifestations at the histological

cellular

and clinical levels. Rheumatologists have marked them as two entirely distinct arthropathies. Given recent discoveries in disease initiation and progression

potential mechanisms

cellular signaling pathways

and ongoing clinical therapeutics

there are now more opportunities for discovering osteoarthritis drugs. This review summarized the osteoarthritis and psoriasis arthritis signaling pathways

crosstalk between BMP

WNT

TGF-β

VEGF

TLR

and FGF signaling pathways

biomarkers

and anatomical pathologies. Through bench research

we demonstrated that regenerative medicine is a promising alternative for treating osteoarthritis by highlighting significant scientific discoveries on entheses

multiple signaling blockers

and novel molecules such as immunoglobulin new antigen receptors targeted for potential drug evaluation. Furthermore

we offered valuable therapeutic approaches with a multidisciplinary strategy to treat patients with osteoarthritis or psoriasis arthritis in the coming future in the clinic.

关键词

Keywords

New antigen receptorOsteoarthritisPhysiopathologyPsoriasis arthritisSignaling pathway

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