Single-cell RNA sequencing in juvenile idiopathic arthritis

Xiwen Luo; Xuemei Tang

doi:10.1016/j.gendis.2023.04.014

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Single-cell RNA sequencing in juvenile idiopathic arthritis

Review article | 更新时间：2024-02-04

- Single-cell RNA sequencing in juvenile idiopathic arthritis
- Genes & Diseases Vol. 11, Issue 2, (2024)
- 作者机构：
  
  1. Department of Rheumatology and Immunology, Children’s Hospital of Chongqing Medical University,Chongqing,China,400014
  2. Chongqing Key Laboratory of Child Infection and Immunity, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University,Chongqing,China,400014
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.04.014
  CLC：
- Published：2024，
  
  Published Online：1 March 2024，
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Xiwen Luo, Xuemei Tang. Single-cell RNA sequencing in juvenile idiopathic arthritis. [J]. Genes & Diseases 11(2).(2024)
DOI：

Xiwen Luo, Xuemei Tang. Single-cell RNA sequencing in juvenile idiopathic arthritis. [J]. Genes & Diseases 11(2).(2024) DOI： 10.1016/j.gendis.2023.04.014.

摘要

Abstract

Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children

with onset before age 16 and lasting for more than 6 weeks. JIA is a highly heterogeneous condition with various consequences for health and quality of life. For some JIA patients

early detection and intervention remain challenging. As a result

further investigation of the complex and unknown mechanisms underlying JIA is required. Advances in technology now allow us to describe the biological heterogeneity and function of individual cell populations in JIA. Through this review

we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis.

关键词

Keywords

Juvenile idiopathic arthritisMacrophageMacrophage activation syndromeMonocyteSingle-cell RNA sequencingSynoviocyteT cell

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