The journey towards physiology and pathology: Tracing the path of neuregulin 4

Min Chen; Jieying Zhu; Hongyang Luo; Wangjing Mu; Liang Guo

doi:10.1016/j.gendis.2023.03.021

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The journey towards physiology and pathology: Tracing the path of neuregulin 4

Review article | 更新时间：2024-02-04

- The journey towards physiology and pathology: Tracing the path of neuregulin 4
- Genes & Diseases Vol. 11, Issue 2, (2024)
- 作者机构：
  
  School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport,Shanghai,China,200438
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.03.021
  CLC：
- Published：2024，
  
  Published Online：1 March 2024，
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Min Chen, Jieying Zhu, Hongyang Luo, et al. The journey towards physiology and pathology: Tracing the path of neuregulin 4. [J]. Genes & Diseases 11(2).(2024)
DOI：

Min Chen, Jieying Zhu, Hongyang Luo, et al. The journey towards physiology and pathology: Tracing the path of neuregulin 4. [J]. Genes & Diseases 11(2).(2024) DOI： 10.1016/j.gendis.2023.03.021.

摘要

Abstract

Neuregulin 4 (Nrg4)

an epidermal growth factor (EGF) family member

can bind to and activate the ErbB4 receptor tyrosine kinase. Nrg4 has five different isoforms by alternative splicing and performs a wide variety of functions. Nrg4 is involved in a spectrum of physiological processes including neurobiogenesis

lipid metabolism

glucose metabolism

thermogenesis

and angiogenesis. In pathological processes

Nrg4 inhibits inflammatory factor levels and suppresses apoptosis in inflammatory diseases. In addition

Nrg4 could ameliorate obesity

insulin resistance

and cardiovascular diseases. Furthermore

Nrg4 improves non-alcoholic fatty liver disease (NAFLD) by promoting autophagy

improving lipid metabolism

and inhibiting cell death of hepatocytes. Besides

Nrg4 is closely related to the development of cancer

hyperthyroidism

and some other diseases. Therefore

elucidation of the functional role and mechanisms of Nrg4 will provide a clearer view of the therapeutic potential and possible risks of Nrg4.

关键词

Keywords

AngiogenesisCardiovascular diseasesInflammationInsulin resistanceLipid and glucose metabolismNAFLDNeurobiogenesisObesity

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