The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities

Minjie Wu; Heng Dong; Chao Xu; Mengqing Sun; Haojin Gao; Fangtian Bu; Jianxiang Chen

doi:10.1016/j.gendis.2023.03.012

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The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities

Review article | 更新时间：2024-02-04

- The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities
- Genes & Diseases Vol. 11, Issue 2, (2024)
- 作者机构：
  
  1. College of Pharmacy and Department of Hepatology, Institute of Hepatology and Metabolic Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University,Zhejiang,Hangzhou,China,311121
  2. Laboratory of Cancer Genomics, Division of Cellular and Molecular Research, National Cancer Centre,Singapore,Singapore,169610
  3. Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University,Zhejiang,Hangzhou,China,311121
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.03.012
  CLC：
- Published：2024，
  
  Published Online：1 March 2024，
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Minjie Wu, Heng Dong, Chao Xu, et al. The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities. [J]. Genes & Diseases 11(2).(2024)
DOI：

Minjie Wu, Heng Dong, Chao Xu, et al. The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities. [J]. Genes & Diseases 11(2).(2024) DOI： 10.1016/j.gendis.2023.03.012.

摘要

Abstract

B-cell CLL/lymphoma 9 (BCL9) is considered a key developmental regulator and a well-established oncogenic driver in multiple cancer types

mainly through potentiating the Wnt/β-catenin signaling. However

increasing evidences indicate that BCL9 also plays multiple Wnt-independent roles. Herein

we summarized the updates of the canonical and non-canonical functions of BCL9 in cellular

physiological

or pathological processes. Moreover

we also concluded that the targeted inhibitors disrupt the interaction of β-catenin with BCL9 reported recently.

关键词

Keywords

BCL9DevelopmentImmunityMultifaceted functionsTherapeutic targetTumorigenesis

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