Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

Yu Zhang; Xinliang Gu; Yang Li; Yuejiao Huang; Shaoqing Ju

doi:10.1016/j.gendis.2023.02.053

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Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

Review article | 更新时间：2024-02-04

- Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers
- Genes & Diseases Vol. 11, Issue 2, (2024)
- 作者机构：
  
  1. Department of Medical Oncology, Affiliated Hospital of Nantong University,Jiangsu,Nantong,China,226001
  2. Medical School of Nantong University, Nantong University,Jiangsu,Nantong,China,226001
  3. Research Center of Clinical Medicine, Affiliated Hospital of Nantong University,Jiangsu,Nantong,China,226001
  4. Department of Laboratory Medicine, Affiliated Hospital of Nantong University,Jiangsu,Nantong,China,226001
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.053
  CLC：
- Published：2024，
  
  Published Online：1 March 2024，
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Yu Zhang, Xinliang Gu, Yang Li, et al. Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers. [J]. Genes & Diseases 11(2).(2024)
DOI：

Yu Zhang, Xinliang Gu, Yang Li, et al. Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers. [J]. Genes & Diseases 11(2).(2024) DOI： 10.1016/j.gendis.2023.02.053.

摘要

Abstract

With the development of sequencing technology

transfer RNA (tRNA)-derived small RNAs (tsRNAs) have received extensive attention as a new type of small noncoding RNAs. Based on the differences in the cleavage sites of nucleases on tRNAs

tsRNAs can be divided into two categories

tRNA halves (tiRNAs) and tRNA-derived fragments (tRFs)

each with specific subcellular localizations. Additionally

the biogenesis of tsRNAs is tissue-specific and can be regulated by tRNA modifications. In this review

we first elaborated on the classification and biogenesis of tsRNAs. After summarizing the latest mechanisms of tsRNAs

including transcriptional gene silencing

post-transcriptional gene silencing

nascent RNA silencing

translation regulation

rRNA regulation

and reverse transcription regulation

we explored the representative biological functions of tsRNAs in tumors. Furthermore

this review summarized the clinical value of tsRNAs in cancers

thus providing theoretical support for their potential as novel biomarkers and therapeutic targets.

关键词

Keywords

BiogenesisBiological functionCancerMechanismTherapeutic strategytsRNAs

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