<em>Mapk7</em> deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

Chengzhi Wu; Hengyu Liu; Dongmei Zhong; Xiaoming Yang; Zhiheng Liao; Yuyu Chen; Shun Zhang; Deying Su; Baolin Zhang; Chuan Li; Liru Tian; Caixia Xu; Peiqiang Su

doi:10.1016/j.gendis.2023.02.012

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Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

Full-length article | 更新时间：2024-02-04

- Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling
- Genes & Diseases Vol. 11, Issue 2, (2024)
- 作者机构：
  
  1. Department of Orthopedics, Renmin Hospital of Wuhan University,Hubei,Wuhan,China,430060
  2. Guangdong Provincial Key Laboratory of Proteomics and State Key Laboratory of Organ Failure Research, School of Basic Medical Sciences, Southern Medical University,Guangdong,Guangzhou,China,510515
  3. Precision Medicine Institute, The First Affiliated Hospital of Sun Yat-sen University,Guangdong,Guangzhou,China,510080
  4. Research Center for Translational Medicine, The First Affiliated Hospital of Sun Yat-sen University,Guangdong,Guangzhou,China,510080
  5. Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University,Guangdong,Guangzhou,China,510080
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.02.012
  CLC：
- Published：2024，
  
  Published Online：1 March 2024，
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Chengzhi Wu, Hengyu Liu, Dongmei Zhong, et al. Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling. [J]. Genes & Diseases 11(2).(2024)
DOI：

Chengzhi Wu, Hengyu Liu, Dongmei Zhong, et al. Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling. [J]. Genes & Diseases 11(2).(2024) DOI： 10.1016/j.gendis.2023.02.012.

摘要

Abstract

Mutation of the MAPK7 gene was related to human scoliosis.

Mapk7

regulated the development of limb bones and skulls in mice. However

the role of MAPK7 in vertebral development is still unclear. In this study

we constructed

Col2a1-cre; Mapk7

f/f

transgenic mouse model to delete

Mapk7

in cartilage

which displayed kyphosis and osteopenia. Mechanistically

Mapk7

loss decreased MEF2C expression and thus activated PTEN to oppose PI3K/AKT signaling in vertebral growth plate chondrocytes

which impaired chondrocyte hypertrophy and attenuated vertebral ossification.

In vivo

systemic pharmacological activation of AKT rescued impaired chondrocyte hypertrophy and alleviated mouse vertebral defects caused by

Mapk7

deficiency. Our study firstly clarified the mechanism by which MAPK7 was involved in vertebral development

which might contribute to understanding the pathology of spinal deformity and provide a basis for the treatment of developmental disorders of the spine.

关键词

Keywords

Chondrocyte hypertrophyGrowth plateKyphosisMAPK7MEF2COsteopeniaPI3K/AktPTEN

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Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

DOI：10.1016/j.gendis.2023.02.012

摘要

Abstract

关键词

Keywords

references