The physicochemical characteristics of RNA admit non-coding RNAs to perform a different range of biological acts through various mechanisms and are involved in regulating a diversity of fundamental processes. Notably

some reports of pathological conditions have proved abnormal expression of many non-coding RNAs guides the ailment. Vault RNAs are a class of non-coding RNAs containing stem regions or loops with well-conserved sequence patterns that play a fundamental role in the function of vault particles through RNA-ligand

RNA–RNA

or RNA-protein interactions. Taken together

vault RNAs have been proposed to be involved in a variety of functions such as cell proliferation

nucleocytoplasmic transport

intracellular detoxification processes

multidrug resistance

apoptosis

and autophagy

and serve as microRNA precursors and signaling pathways. Despite decades of investigations devoted

the biological function of the vault particle or the vault RNAs is not yet completely cleared. In this review

the current scientific assertions of the vital vault RNAs functions were discussed.