Signaling pathways governing the behaviors of leukemia stem cells

Shirin Azizidoost; Ava Nasrolahi; Mohadeseh Sheykhi-Sabzehpoush; Amir Anbiyaiee; Seyed Esmaeil Khoshnam; Maryam Farzaneh; Shahab Uddin

doi:10.1016/j.gendis.2023.01.008

您当前的位置：

首页 >

文章列表页 >

Signaling pathways governing the behaviors of leukemia stem cells

Review article | 更新时间：2024-02-04

- Signaling pathways governing the behaviors of leukemia stem cells
- Genes & Diseases Vol. 11, Issue 2, (2024)
- 作者机构：
  
  1. Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
  2. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
  3. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
  4. Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran 219367,Iran,2411
  5. Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha,Qatar,3050
  6. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
  7. Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 619367,Iran,3111
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2023.01.008
  CLC：
- Published：2024，
  
  Published Online：1 March 2024，
扫描看全文
Shirin Azizidoost, Ava Nasrolahi, Mohadeseh Sheykhi-Sabzehpoush, et al. Signaling pathways governing the behaviors of leukemia stem cells. [J]. Genes & Diseases 11(2).(2024)
DOI：

Shirin Azizidoost, Ava Nasrolahi, Mohadeseh Sheykhi-Sabzehpoush, et al. Signaling pathways governing the behaviors of leukemia stem cells. [J]. Genes & Diseases 11(2).(2024) DOI： 10.1016/j.gendis.2023.01.008.

摘要

Abstract

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia

understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways

including Notch

Wnt

Hedgehog

and STAT3. LSCs are highly proliferative cells that stimulate tumor initiation

migration

EMT

and drug resistance. This review summarizes cellular pathways that stimulate and prevent LSCs' self-renewal

metastasis

and tumorigenesis.

关键词

Keywords

LeukemiaLeukemia stem cellsPathogenesisSignaling pathwaysStem cells

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

The essential roles of m⁶A modification in osteogenesis and common bone diseases

TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities

The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer

Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

Related Author

Tong-Chuan He

Michael Yu

Kevin Qin

Jiaming Fan

Guozhi Zhao

Piao Zhao

Wei Zeng

Connie Chen

Related Institution

Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, The School of Laboratory Medicine, Chongqing Medical University

Department of Urology, The First Affiliated Hospital of Chongqing Medical University

School of Medicine, Rosalind Franklin University of Medicine and Science, North Chicago

Department of Clinical Laboratory Medicine, Shanghai Jiaotong University School of Medicine

Laboratory of Craniofacial Suture Biology and Development, Department of Surgery Section of Plastic Surgery, The University of Chicago Medical Center

⁰