The generation and use of animal models of osteosarcoma in cancer research

Feifei Pu; Haoyu Guo; Deyao Shi; Fengxia Chen; Yizhong Peng; Xin Huang; Jianxiang Liu; Zhicai Zhang

doi:10.1016/j.gendis.2022.12.021

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The generation and use of animal models of osteosarcoma in cancer research

Review article | 更新时间：2024-02-04

- The generation and use of animal models of osteosarcoma in cancer research
- Genes & Diseases Vol. 11, Issue 2, (2024)
- 作者机构：
  
  1. Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University,Hubei,Wuhan,China,430071
  2. Department of Orthopedics, Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital), Tongji Medical College, Huazhong University of Science and Technology,Hubei,Wuhan,China,430022
  3. Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University,Hubei,Wuhan,China,430071
  4. Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Hubei,Wuhan,China,430022
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.12.021
  CLC：
- Published：2024，
  
  Published Online：1 March 2024，
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Feifei Pu, Haoyu Guo, Deyao Shi, et al. The generation and use of animal models of osteosarcoma in cancer research. [J]. Genes & Diseases 11(2).(2024)
DOI：

Feifei Pu, Haoyu Guo, Deyao Shi, et al. The generation and use of animal models of osteosarcoma in cancer research. [J]. Genes & Diseases 11(2).(2024) DOI： 10.1016/j.gendis.2022.12.021.

摘要

Abstract

Osteosarcoma is the most common malignant bone tumor affecting children and adolescents. Currently

the most common treatment is surgery combined with neoadjuvant chemotherapy. Although the survival rate of patients with osteosarcoma has improved in recent years

it remains poor when the tumor(s) progress and distant metastases develop. Therefore

better animal models that more accurately replicate the natural progression of the disease are needed to develop improved prognostic and diagnostic markers

as well as targeted therapies for both primary and metastatic osteosarcoma. The present review described animal models currently being used in research investigating osteosarcoma

and their characteristics

advantages

and disadvantages. These models may help elucidate the pathogenic mechanism(s) of osteosarcoma and provide evidence to support and develop clinical treatment strategies.

关键词

Keywords

Animal modelCancerOsteosarcomaPathogenic mechanismTranslational research

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