The emerging role of snoRNAs in human disease

Xinhai Zhang; Chenglong Wang; Shujun Xia; Fei Xiao; Jianping Peng; Yuxuan Gao; Fengbin Yu; Chuandong Wang; Xiaodong Chen

doi:10.1016/j.gendis.2022.11.018

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The emerging role of snoRNAs in human disease

Review article | 更新时间：2023-08-29

- The emerging role of snoRNAs in human disease
- Genes & Diseases Vol. 10, Issue 5, (2023)
- 作者机构：
  
  1. Department of Orthopaedic Surgery, Second Hospital of Shanxi Medical University,Shanxi,Taiyuan,China,030001
  2. Department of Orthopedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM),Shanghai,China,200092
  3. Department of Orthopaedics, The 72nd Group Army Hospital of PLA,Zhejiang,Huzhou,China,313000
  4. Ultrasound Department, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM),Shanghai,China,200025
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.11.018
  CLC：
- Published：2023，
  
  Published Online：1 September 2023，
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Xinhai Zhang, Chenglong Wang, Shujun Xia, et al. The emerging role of snoRNAs in human disease. [J]. Genes & Diseases 10(5).(2023)
DOI：

Xinhai Zhang, Chenglong Wang, Shujun Xia, et al. The emerging role of snoRNAs in human disease. [J]. Genes & Diseases 10(5).(2023) DOI： 10.1016/j.gendis.2022.11.018.

摘要

Abstract

Small nucleolar RNAs (snoRNAs) play critical roles in various biological processes. The aberrant expression or depletion of snoRNAs is related to various diseases. In previous research

most of the snoRNAs were categorized as C/D box snoRNAs and H/ACA box snoRNAs

whose typical functions were thought of as regulation of 2′-O-ribose methylation and pseudouridylation of ribosome RNAs

respectively. However

in the past two decades

studies have revealed an increasing number of snoRNAs without specific targets or determined cell functions. These findings indicated that some potential roles of snoRNAs are still unknown. Numerous studies have indicated the correlation of snoRNAs with human diseases. SnoRNAs play various roles in abundant biological processes

and they have great potential in controlling human diseases. This new and rising field could benefit from investigations of the disease pathogenesis

biomarker identification

and the determination of novel therapeutic targets. This review summarized the reports on snoRNAs and the regulation of different diseases in recent years.

关键词

Keywords

CancerGenetic diseaseInflammationMetabolismSmall nucleolar RNAs

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