The role of TGF-β in the tumor microenvironment of pancreatic cancer

Qiang Luo; Ziquan Hu; Hongcheng Zhao; Yanmei Fan; Xiancong Tu; Yueqing Wang; Xiaowen Liu

doi:10.1016/j.gendis.2022.10.019

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The role of TGF-β in the tumor microenvironment of pancreatic cancer

Review article | 更新时间：2023-08-29

- The role of TGF-β in the tumor microenvironment of pancreatic cancer
- Genes & Diseases Vol. 10, Issue 4, (2023)
- 作者机构：
  
  Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University,Hubei,Yichang,China,443003
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.019
  CLC：
- Published：2023，
  
  Published Online：1 July 2023，
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Qiang Luo, Ziquan Hu, Hongcheng Zhao, et al. The role of TGF-β in the tumor microenvironment of pancreatic cancer. [J]. Genes & Diseases 10(4).(2023)
DOI：

Qiang Luo, Ziquan Hu, Hongcheng Zhao, et al. The role of TGF-β in the tumor microenvironment of pancreatic cancer. [J]. Genes & Diseases 10(4).(2023) DOI： 10.1016/j.gendis.2022.10.019.

摘要

Abstract

Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and antitumor activities

depending on tumor microenvironment. The interaction between TGF-β signaling and the tumor microenvironment in PC is complex. Here

we reviewed the role of TGF-β in the tumor microenvironment of PC

highlighting producers of TGF-β and TGF-β responders in the tumor microenvironment of PC.

关键词

Keywords

Cancer therapyPancreatic cancerSmad 4Transforming growth factor-βTumor microenvironment

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Related Institution

Departments of Gastroenterology, Changhai Hospital, Second Military Medical University

Center for Pancreatic Cancer Research, The South China University of Technology School of Medicine

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