The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications

Dan Huang; Gege Liu; Zhiyi Xu; Shushu Chen; Cuili Wang; Dewei Liu; Jiahao Cao; Junfen Cheng; Bin Wu; Dong Wu

doi:10.1016/j.gendis.2022.10.017

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The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications

Review article | 更新时间：2023-08-29

- The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications
- Genes & Diseases Vol. 10, Issue 4, (2023)
- 作者机构：
  
  1. Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Guangdong Medical University,Guangdong,Zhanjiang,China,524000
  2. Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University,Guangdong,Zhanjiang,China,524000
  3. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa,Macao SAR,China,999078
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.017
  CLC：
- Published：2023，
  
  Published Online：1 July 2023，
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Dan Huang, Gege Liu, Zhiyi Xu, et al. The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications. [J]. Genes & Diseases 10(4).(2023)
DOI：

Dan Huang, Gege Liu, Zhiyi Xu, et al. The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis: Therapeutic implications. [J]. Genes & Diseases 10(4).(2023) DOI： 10.1016/j.gendis.2022.10.017.

摘要

Abstract

Placental growth factor (PlGF) is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor (VEGF). PlGF expression is upregulated in patients with bronchial asthma

suggesting that it plays a role in the pathogenesis of asthma. Bronchial asthma is characterized by chronic airway inflammation and airway hyperresponsiveness (AHR). After recurrent asthma attacks

pulmonary fibrosis develops and leads to airway remodeling and a further decline in lung function. In this review

we focused on the pivotal role of PlGF in chronic airway inflammation

AHR

and airway remodeling during bronchial asthma. Furthermore

we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma.

关键词

Keywords

AHRAirway remodelingBronchial asthmaChronic airway inflammationPlGF

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