Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases

Hongliang Liu; Wenjing Hao; Jiao Yang; Yuliang Zhang; Xinfang Wang; Chunming Zhang

doi:10.1016/j.gendis.2022.10.015

您当前的位置：

首页 >

文章列表页 >

Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases

Review article | 更新时间：2023-08-29

- Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases
- Genes & Diseases Vol. 10, Issue 5, (2023)
- 作者机构：
  
  1. Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University,Shanxi,Taiyuan,China,030001
  2. Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University,Shanxi,Taiyuan,China,030001
  3. Department of Cell Biology and Genetics, The Basic Medical School of Shanxi Medical University,Shanxi,Taiyuan,China,030001
  4. Department of Anatomy, The Basic Medical School of Shanxi Medical University,Shanxi,Taiyuan,China,030001
  5. Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University,Shanxi,Taiyuan,China,030001
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.10.015
  CLC：
- Published：2023，
  
  Published Online：1 September 2023，
扫描看全文
Hongliang Liu, Wenjing Hao, Jiao Yang, et al. Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases. [J]. Genes & Diseases 10(5).(2023)
DOI：

Hongliang Liu, Wenjing Hao, Jiao Yang, et al. Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases. [J]. Genes & Diseases 10(5).(2023) DOI： 10.1016/j.gendis.2022.10.015.

摘要

Abstract

Circular RNAs (circRNAs) are a special class of single-stranded RNA molecules with covalently closed loops widely expressed in eukaryotic organisms. CircRNAs have long been considered to play important roles in various physiological and pathological processes as non-coding RNAs. However

circRNAs have recently garnered considerable attention due to their ability to be translated into peptides/proteins via internal ribosome entry site- or N6-methyladenosine-mediated pathways or rolling translation mechanisms. Furthermore

dysregulation of translatable circRNAs and their encoded proteins has been associated with developing and progressing diseases such as cancer. This review aims to summarize the driving mechanisms of circRNA translation and the available strategies in circRNA translation research. The main focus is on the emerging biological functions of translatable circRNAs

their regulatory mechanisms

and potential clinical applications in human diseases to provide new perspectives on disease diagnosis

prognosis

and targeted therapy.

关键词

Keywords

Circular RNAClinical applicationsFunctionPeptideTranslation

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases

Critical involvement of circular RNAs in virus-associated cancers

Emerging roles of circular RNAs in stem cells

Related Author

Lutao Du

Ghazal Mohseni

Tianshu Miao

Yinghui Zhao

Hong Zhang

Yaqi Dong

Xinhui Wang

Yuping Shen

Related Institution

Department of Clinical Laboratory, Fuling Hospital, Chongqing University

Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory

Suzhou Research Institute of Shandong University

Shandong Engineering & Technology Research Center for Tumor Marker Detection

Department of Clinical Laboratory, The Second Hospital of Shandong University

⁰