lternative splicing (AS) produces the different mRNA splicing bodies

which are then translated into multiple protein isoforms and participate in various biological functions. With a deeper understanding of alternative splicing through the study of transcriptomes using high-throughput sequencing-based methods

the correlation between aberrant AS and diseases triggered a great concern

especially abnormal AS and cancer. Medulloblastoma (MB) is an intracranial tumor in children. Sonic hedgehog MB (SHH-MB) accounted for approximately 30% of MB

which is associated with the activation of SHH signaling. Growing evidence shows that aberrant AS is closely related to the tumorigenesis of MB. Here

we briefly introduced the AS and its mechanism. Next

we described canonical/noncanonical hedgehog signaling and its correlation with MB. The main description focused on AS of various regulators in canonical hedgehog signaling in MB. In addition

we also described AS of various regulators in noncanonical hedgehog signaling. Meanwhile

activated hedgehog signaling also induces AS in MB. Then

we pointed out that aberrant AS of hedgehog signaling is associated with different MB subgroups. Finally

we summarized the therapeutic applications of targeted AS in cancer treatment. In summary

further understanding of AS in SHH-MB could develop therapeutic targets for splicing factors which may be a novel therapeutic strategy.