The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

Junyang Huang; Kun Zhang; Ruolin Du; Wanling Liu; Haijun Zhang; Tian Tian; Yazhou Wang; Tieying Yin

doi:10.1016/j.gendis.2022.08.015

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The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

Review article | 更新时间：2023-08-29

- The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation
- Genes & Diseases Vol. 10, Issue 5, (2023)
- 作者机构：
  
  1. School of Medicine, Chongqing University,Chongqing,China,400030
  2. Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University,Chongqing,China,400030
  3. Department of Vascular & Intervention, Tenth Peoples' Hospital of Tongji University,Shanghai,China,200072
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.08.015
  CLC：
- Published：2023，
  
  Published Online：1 September 2023，
扫描看全文
Junyang Huang, Kun Zhang, Ruolin Du, et al. The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation. [J]. Genes & Diseases 10(5).(2023)
DOI：

Junyang Huang, Kun Zhang, Ruolin Du, et al. The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation. [J]. Genes & Diseases 10(5).(2023) DOI： 10.1016/j.gendis.2022.08.015.

摘要

Abstract

In recent years

cardiovascular health problems are becoming more and more serious. At the same time

mechanical stimulation closely relates to cardiovascular health. In this context

Piezo1

which is very sensitive to mechanical stimulation

has attracted our attention. Here

we review the critical significance of Piezo1 in mechanical stimulation of endothelial cells

NO production

lipid metabolism

DNA damage protection

the development of new blood vessels and maturation

narrowing of blood vessels

blood pressure regulation

vascular permeability

insulin sensitivity

and maintenance of red blood cell function. Besides

Piezo1 may participate in the occurrence and development of atherosclerosis

diabetes

hypertension

and other cardiovascular diseases. It is worth noting that Piezo1 has dual effects on maintaining cardiovascular health. On the one hand

the function of Piezo1 is necessary to maintain cardiovascular health; on the other hand

under some extreme mechanical stimulation

the overexpression of Piezo1 may bring adverse factors such as inflammation. Therefore

this review discusses the Janus-faced role of Piezo1 in maintaining cardiovascular health and puts forward new ideas to provide references for gene therapy or nanoagents targeting Piezo1.

关键词

Keywords

AtherosclerosisCardiovascular diseaseEndothelial cells (ECs)Mechanical stimulationPiezo1

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Related Author

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Related Institution

Division of Infectious Diseases, Chongqing Public Health Medical Center

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China

Department of Vascular Surgery, First Affiliated Hospital, Army Medical University (Third Military University)

Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State Key Laboratory of Mechanical Transmission, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University

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