TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities

Yunfei Huo; Ke Cao; Buxin Kou; Mengyin Chai; Shuangshuang Dou; Dexi Chen; Ying Shi; Xiaoni Liu

doi:10.1016/j.gendis.2022.08.014

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TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities

Review article | 更新时间：2023-08-29

- TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities
- Genes & Diseases Vol. 10, Issue 5, (2023)
- 作者机构：
  
  Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University,Beijing,China,100069
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.08.014
  CLC：
- Published：2023，
  
  Published Online：1 September 2023，
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Yunfei Huo, Ke Cao, Buxin Kou, et al. TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities. [J]. Genes & Diseases 10(5).(2023)
DOI：

Yunfei Huo, Ke Cao, Buxin Kou, et al. TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities. [J]. Genes & Diseases 10(5).(2023) DOI： 10.1016/j.gendis.2022.08.014.

摘要

Abstract

Malignant tumor is still a major problem worldwide. During tumorigenesis or tumor development

tumor suppressor p53-binding protein 2 (TP53BP2)

also known as apoptosis stimulating protein 2 of p53 (ASPP2)

plays a critical role in p53 dependent and independent manner. Expression of TP53BP2 is highly correlated with the prognosis and survival rate of malignant tumor patients. TP53BP2 can interact with p53

NF-κB p65

Bcl-2

HCV core protein

PP1

YAP

CagA

RAS

PAR3

and other proteins to regulate cell function. Moreover

TP53BP2 can also regulate the proliferation

apoptosis

autophagy

migration

EMT and drug resistance of tumor cells through downstream signaling pathways

such as NF-κB

RAS/MAPK

mevalonate

TGF-β1

PI3K/AKT

aPKC-ι/GLI1 and autophagy pathways. As a potential therapeutic target

TP53BP2 has been attracted more attention. We review the role of TP53BP2 in tumorigenesis or tumor development and the signal pathway involved in TP53BP2

which may provide more deep insight and strategies for tumor treatment.

关键词

Keywords

Binding proteinsSignaling pathwaysTP53TP53BP2TumorigenesisTumor development

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