Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy

Hong Li; Tingli Liu; Yongchun Yang; William C. Cho; Robin J. Flynn; Majid Fasihi Harandi; Houhui Song; Xuenong Luo; Yadong Zheng

doi:10.1016/j.gendis.2022.08.013

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Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy

Review article | 更新时间：2023-08-29

- Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy
- Genes & Diseases Vol. 10, Issue 4, (2023)
- 作者机构：
  
  1. Graduate Studies Office, Department of Research, Innovation and Graduate Studies, Waterford Institute of Technology, X91 K0EK,Ireland
  2. Department of Clinical Oncology, Queen Elizabeth Hospital,Hong Kong SAR,China,999077
  3. State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences,Gansu,Lanzhou,China,730046
  4. Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool,Liverpool,UK,L3 5RF
  5. Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman 761691,Iran,4115
  6. Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University,Zhejiang,Hangzhou,China,311300
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.08.013
  CLC：
- Published：2023，
  
  Published Online：1 July 2023，
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Hong Li, Tingli Liu, Yongchun Yang, et al. Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy. [J]. Genes & Diseases 10(4).(2023)
DOI：

Hong Li, Tingli Liu, Yongchun Yang, et al. Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy. [J]. Genes & Diseases 10(4).(2023) DOI： 10.1016/j.gendis.2022.08.013.

摘要

Abstract

microRNAs (miRNAs) are a class of non-coding functional small RNA composed of 21–23 nucleotides

having multiple associations with liver fibrosis. Fibrosis-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis types. The former is capable of activating hepatic stellate cells (HSCs) by modulating pro-fibrotic signaling pathways

mainly including TGF-β/SMAD

WNT/β-catenin

and Hedgehog; the latter is responsible for maintenance of the quiescent phenotype of normal HSCs

phenotypic reversion of activated HSCs (aHSCs)

inhibition of HSCs proliferation and suppression of the extracellular matrix-associated gene expression. Moreover

several miRNAs are involved in regulation of liver fibrosis via alternative mechanisms

such as interacting between hepatocytes and other liver cells via exosomes and increasing autophagy of aHSCs. Thus

understanding the role of these miRNAs may provide new avenues for the development of novel interventions against hepatic fibrosis.

关键词

Keywords

DiagnosisHepatic stellate cellLiver fibrosismiRNATherapy

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