Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics

Hafiza Padinharayil; Jinsu Varghese; Mithun Chacko John; Golgodu Krishnamurthy Rajanikant; Cornelia M. Wilson; Minnatallah Al-Yozbaki; Kaviyarasi Renu; Saikat Dewanjee; Rupa Sanyal; Abhijit Dey; Anirban Goutam Mukherjee; Uddesh Ramesh Wanjari; Abilash Valsala Gopalakrishnan; Alex George

doi:10.1016/j.gendis.2022.07.023

您当前的位置：

首页 >

文章列表页 >

Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics

Review article | 更新时间：2023-08-29

- Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics
- Genes & Diseases Vol. 10, Issue 3, (2023)
- 作者机构：
  
  1. Department of Biomedical Sciences, School of Bio-Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu,India,632014
  2. Canterbury Christ Church University, Natural Applied Sciences, Life Sciences Industry Liaison Lab, Discovery Park, Sandwich CT13 9FF, United Kingdom
  3. Department of Life Sciences, Presidency University, Kolkata, West Bengal,India,700073
  4. Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal,India,700032
  5. Department of Medical Oncology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala,India,680005
  6. Jubilee Centre for Medical Research, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala,India,680005
  7. School of Biotechnology, National Institute of Technology, Calicut, Kerala,India,673601
  8. Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University,, Tamil Nadu,Chennai,India,600077
  9. PG & Research Department of Zoology, St. Thomas College, Kozhenchery, Pathanamthitta, Kerala,India,689641
  10. Department of Botany, Bhairab Ganguly College, Feeder Road, Belghoria, Kolkata, West Bengal,India,700056
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.07.023
  CLC：
- Published：2023，
  
  Published Online：1 May 2023，
扫描看全文
Hafiza Padinharayil, Jinsu Varghese, Mithun Chacko John, et al. Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics. [J]. Genes & Diseases 10(3).(2023)
DOI：

Hafiza Padinharayil, Jinsu Varghese, Mithun Chacko John, et al. Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics. [J]. Genes & Diseases 10(3).(2023) DOI： 10.1016/j.gendis.2022.07.023.

摘要

Abstract

Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) provides the foundation for therapeutic advances by promoting molecular targeted and immunotherapies and ensuring accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention

diagnosis

and management

supporting health-care interventions. Global cancer mortality projections from 2016 to 2060 show that cancer will overtake ischemic heart diseases (IHD) as the leading cause of death (18.9 million) immediately after 2030

surpassing non-small cell lung cancer (NSCLC)

which accounts for 85 percent of lung cancers. The clinical stage at the diagnosis is the main prognostic factor in NSCLC therapies. Advanced early diagnostic methods are essential as the initial stages of cancer show reduced mortality compared to the advanced stages. Sophisticated approaches to proper histological classification and NSCLC management have improved clinical efficiency. Although immune checkpoint inhibitors (ICIs) and targeted molecular therapies have refined the therapeutic management of late-stage NSCLC

the specificity and sensitivity of cancer biomarkers should be improved by focusing on prospective studies

followed by their use as therapeutic tools. The liquid biopsy candidates such as circulating tumor cells (CTCs)

circulating cell-free tumor DNA (cfDNA)

tumor educated platelets (TEP)

and extracellular vesicles (EVs) possess cancer-derived biomolecules and aid in tracing: driver mutations leading to cancer

acquired resistance caused by various generations of therapeutic agents

refractory disease

prognosis

and surveillance.

关键词

Keywords

BiomarkerClinical trialEpidemiologyHistologyLiquid biopsyNSCLCTargeted therapy

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Advances in the early diagnosis of hepatocellular carcinoma

Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

Integrative transcriptome analysis identifies MYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration

Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder

Related Author

Weiyi Wang

Chao Wei

Meijia Yu

Yiming Wu

Qingfang Li

Weiqi Hong

Yang Yang

Xiaoyi Hu

Related Institution

Xiamen Amplly Bio-engineering Co., Ltd

Department of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University

Department of Obstetrics and Gynecology, The First Affiliated Hospital, Army Medical University

Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University

Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, The School of Laboratory Medicine, Chongqing Medical University

⁰