Mitochondria-derived small RNAs as diagnostic biomarkers in lung cancer patients through a novel ratio-based expression analysis methodology

Zongtao Yu; Shaoqiu Chen; Zhenming Tang; Ying Tang; Zhougui Ling; Hongwei Wang; Ting Gong; Zitong Gao; Gehan Devendra; Gang Huang; Wei Chen; Youping Deng

doi:10.1016/j.gendis.2022.07.013

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Mitochondria-derived small RNAs as diagnostic biomarkers in lung cancer patients through a novel ratio-based expression analysis methodology

Full-length article | 更新时间：2023-08-29

- Mitochondria-derived small RNAs as diagnostic biomarkers in lung cancer patients through a novel ratio-based expression analysis methodology
- Genes & Diseases Vol. 10, Issue 3, (2023)
- 作者机构：
  
  1. Department of Pulmonary and Critical Care Medicine, The Fourth Affiliated Hospital of Guangxi Medical University,Guangxi,Liuzhou,China,545005
  2. Department of Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi,Xi'an,China,710061
  3. Division Chief Pulmonary & Critical Care Medicine, The Queen’s Medical Center, John A Burns School of Medicine,HI,Honolulu,USA,96813
  4. Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa,HI,Honolulu,USA,96813
  5. Department of Laboratory Medicine, Affiliated Taihe Hospital of Xi'an Jiaotong University Health Science Center,Hubei,Shiyan,China,710061
  6. Molecular Biosciences and Bioengineering Program, College of Tropical Agriculture and Human Resources, The University of Hawaii at Manoa,HI,Honolulu,USA,96822
  7. Division of Research and Development, Decoding Therapeutics Corp, Mt Prospect,IL,USA,60056
  8. Department of Internal Medicine, Rush University Cancer Center, Rush University Medical Center, Kidston House,IL,Chicago,USA,60612
  9. Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences,Shanghai,China,201318
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.07.013
  CLC：
- Published：2023，
  
  Published Online：1 May 2023，
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Zongtao Yu, Shaoqiu Chen, Zhenming Tang, et al. Mitochondria-derived small RNAs as diagnostic biomarkers in lung cancer patients through a novel ratio-based expression analysis methodology. [J]. Genes & Diseases 10(3).(2023)
DOI：

Zongtao Yu, Shaoqiu Chen, Zhenming Tang, et al. Mitochondria-derived small RNAs as diagnostic biomarkers in lung cancer patients through a novel ratio-based expression analysis methodology. [J]. Genes & Diseases 10(3).(2023) DOI： 10.1016/j.gendis.2022.07.013.

摘要

Abstract

Small non-coding RNAs are potential diagnostic biomarkers for lung cancer. Mitochondria-derived small RNA (mtRNA) is a novel regulatory small non-coding RNA that only recently has been identified and cataloged. Currently

there are no reports of studies of mtRNA in human lung cancer. Currently

normalization methods are unstable

and they often fail to identify differentially expressed small non-coding RNAs (sncRNAs). In order to identify reliable biomarkers for lung cancer screening

we used a ratio-based method using mtRNAs newly discovered in human peripheral blood mononuclear cells. In the discovery cohort (AUC = 0.981) and independent validation cohort (AUC = 0.916) the prediction model of eight mtRNA ratios distinguished lung cancer patients from controls. The prediction model will provide reliable biomarkers that will allow blood-based screening to become more feasible and will help make lung cancer diagnosis more accurate in clinical practice.

关键词

Keywords

Lung cancerMitochondria-derived small RNAsPlasmaRatioSmall non-coding RNAs

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