Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies

Liping Wang; Zhe Chen; Guohong Liu; Yunbao Pan

doi:10.1016/j.gendis.2022.07.009

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Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies

Review article | 更新时间：2023-08-29

- Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies
- Genes & Diseases Vol. 10, Issue 3, (2023)
- 作者机构：
  
  1. Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University,Hubei,Wuhan,China,430071
  2. Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University,Hubei,Wuhan,China,430071
  3. Department of Otolaryngology Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan University,Hubei,Wuhan,China,430071
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2022.07.009
  CLC：
- Published：2023，
  
  Published Online：1 May 2023，
扫描看全文
Liping Wang, Zhe Chen, Guohong Liu, et al. Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies. [J]. Genes & Diseases 10(3).(2023)
DOI：

Liping Wang, Zhe Chen, Guohong Liu, et al. Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies. [J]. Genes & Diseases 10(3).(2023) DOI： 10.1016/j.gendis.2022.07.009.

摘要

Abstract

Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However

NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth. This study reviewed the biological properties of NK cells

the dynamic phenotypic changes of NK cells in the TME

and the communication between NK cells and other immune and nonimmune cells.

关键词

Keywords

Cellular communicationImmune checkpointsImmunotherapyNatural killer cellsTumor microenvironment

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